ArticleAnnals of coloproctology2023
The importance of topical metronidazole in the treatment of acute anal fissure: a double-blind study controlled for prospective randomization.
Article in Annals of coloproctology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 15 citations in OpenAlex.
- Assessment of Treatment Effectiveness in Acute and Chronic Anal Fissures.Medicina (Kaunas, Lithuania) · 2026Article
- Local plus oral antibiotics and strict avoidance of constipation is effective and helps prevents surgery in most cases of anal fissure.Annals of coloproctology · 2023Article
- Article
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1 author at 1 institution in 1 country.
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Abstract
purposeAcute anal fissure, a disease characterized by severe pain in the anorectal area, reduces quality of life and becomes chronic absent appropriate treatment. More recently, anaerobic infections have been noted as contributive to etiopathogenesis. This study investigates topical metronidazole's effect in the treatment of acute anal fissure.
methodsOur prospective randomized controlled double-blind study included 2 groups of 100 patients older than 18 years from our General Surgery Clinic with anal fissure complaints for less than 8 weeks. Topical diltiazem treatment was started in group 1, and topical diltiazem and metronidazole treatment in group 2. Pain levels were evaluated by the visual analogue scale (VAS) score, and recovery status was evaluated by physical examination findings ab initio and at the 1st, 4th, and 6th weeks. VAS score levels, demographic, clinical, and recovery status were then compared.
resultsThere was no difference between the groups as to age, sex, pain on defecation, bleeding, constipation, and duration of pain, bleeding and constipation (P>0.05). From week 1, fissure epithelialization and healing rates were higher in group 2 (P<0.001); group 2 VAS score levels were lower than in group 1 (P<0.001) and achieved by group 1 only in week 4 (P=0.073).
conclusionAdding topical metronidazole to treatment reduces the duration and severity of pain, shortens healing time, and increases the healing rate.
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