Evidence map›Paper›PMID 35038770›Full record

ReviewActa paediatrica (Oslo, Norway : 1992)2022

Epigenetics provides a bridge between early nutrition and long-term health and a target for disease prevention.

Benazir Siddeek, Umberto Simeoni

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  9. Artificial plasticenta: how polystyrene nanoplastics affectFrontiers in cell and developmental biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Benazir SiddeekDOHaD Laboratory, Division of Pediatrics, Woman-Mother-Child-Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2764-6656
Umberto SimeoniDOHaD Laboratory, Division of Pediatrics, Woman-Mother-Child-Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
University Hospital of Lausanne · CH

Funding

Open Access Funding provided by Universite de Lausanne
6 · The paper itself

Abstract

Exposure to nutritional imbalance during early life can influence disease risk lifelong and across generations. In this long-term conditioning, epigenetics constitutes a key mechanism. They bridge environmental cues and the expression of genes involved in the setting of long-standing biological regulations in numerous organs and species. Epigenetic marks are proposed as innovative diagnostic biomarkers and potential targets in the prevention of diseases. However, a number of uncertainties make them difficult to use in clinical approaches in the context of early exposure to nutritional challenge. In conclusion, active investigations in this field are still needed before clinical applications are considered.

Indexed as

Epigenesis, GeneticNutritional StatusHumansearly nutritionepigenetics and long-term health

Identifiers

PMID35038770
PMCPMC9305224
OpenAlexW4206388200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.