Trial reportJournal of affective disorders2022
Enhancing cognitive restructuring with concurrent fMRI-guided neurostimulation for emotional dysregulation-A randomized controlled trial.
Trial report in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06333925 (Using Neurostimulation to Accelerate Change in Misophonia), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Noninvasive brain stimulation combined with evidence-based psychotherapy for psychiatric disorders: A meta-analysis of optimal implementation parameters.Neuroscience and biobehavioral reviews · 2026Pooled it
- Telehealth tDCS to reduce cannabis use: A pilot RCT in multiple sclerosis as a framework for generalized use.Drug and alcohol dependence · 2025Trial
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Low Emotional Awareness and Altered Frontostriatal Functional Connectivity During Reward Processing Prospectively Predict Depressive Symptoms in At-Risk Youth.Journal of child and adolescent psychopharmacology · 2026Article
- Patterns of shared and differential neural activity in misophonia and non-misophonic clinical emotional dysregulation.BMC psychiatry · 2026Article
- The power of context: Enhancing repetitive transcranial magnetic stimulation effects through skillful behavior.Behavioural brain research · 2026Article
- Neuropsychological Mechanisms Associated with the Effectiveness of AI-Delivered Health Promotion Programs: A Comprehensive Meta-Analysis.Brain sciences · 2026Review
- Noninvasive brain stimulation combined with evidence-based psychotherapy for psychiatric disorders: A meta-analysis of optimal implementation parameters.medRxiv : the preprint server for health sciences · 2026Article
- Regulating Negative Autobiographical Memories: An fMRI Investigation of Reappraisal and Distraction in Middle-aged and Older Adults.Journal of cognitive neuroscience · 2026Article
- Consensus guidelines for the use of concurrent TMS-fMRI in cognitive and clinical neuroscience.Nature protocols · 2026Review
- Advances in Neuroimaging and Deep Learning for Emotion Detection: A Systematic Review of Cognitive Neuroscience and Algorithmic Innovations.Diagnostics (Basel, Switzerland) · 2025Review
- Targeting VMPFC-amygdala circuit with TMS in substance use disorder: A mechanistic framework.Addiction biology · 2025Article
- Mapping a pathway to improved neuropsychiatric treatments with precision transcranial magnetic stimulation.Science advances · 2022Review
- The neurobiology of misophonia and implications for novel, neuroscience-driven interventions.Frontiers in neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundTransdiagnostic clinical emotional dysregulation is a key component of many mental health disorders and offers an avenue to address multiple disorders with one transdiagnostic treatment. In the current study, we pilot an intervention that combines a one-time teaching and practice of cognitive restructuring (CR) with repetitive transcranial magnetic stimulation (rTMS), targeted based on functional magnetic resonance imaging (fMRI).
methodsThirty-seven clinical adults who self-reported high emotional dysregulation were enrolled in this randomized, double-blind, placebo-controlled trial. fMRI was collected as participants were reminded of lifetime stressors and asked to downregulate their distress using CR tactics. fMRI BOLD data were analyzed to identify the cluster of voxels within the left dorsolateral prefrontal cortex (dlPFC) with the highest activation when participants attempted to downregulate, versus passively remember, distressing memories. Participants underwent active or sham rTMS (10 Hz) over the left dlPFC target while practicing CR following emotional induction using recent autobiographical stressors.
resultsReceiving active versus sham rTMS led to significantly higher high frequency heart rate variability during regulation, lower regulation duration during the intervention, and higher likelihood to use CR during the week following the intervention. There were no differences between conditions when administering neurostimulation alone without the CR skill and compared to sham. Participants in the sham versus active condition experienced less distress the week after the intervention. There were no differences between conditions at the one-month follow up.
conclusionThis study demonstrated that combining active rTMS with emotion regulation training for one session significantly enhances emotion regulation and augments the impact of training for as long as a week. These findings are a promising step towards a combined intervention for transdiagnostic emotion dysregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.