Evidence map›Paper›PMID 35038407›Full record

Trial reportJournal of the American Medical Directors Association2022

Pragmatic Trial of Personalized Music for Agitation and Antipsychotic Use in Nursing Home Residents With Dementia.

Ellen M McCreedy, Anthony Sisti, Roee Gutman, Laura Dionne, James L Rudolph, Rosa Baier, Kali S Thomas, Miranda B Olson, Esme E Zediker, Rebecca Uth and 2 more

Open access · greenAbstract readRandomized Controlled TrialPragmatic Clinical Trial
In one paragraph

Trial report in Journal of the American Medical Directors Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Music-based therapeutic interventions for people with dementia.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Ellen M McCreedyCenter for Gerontology & Healthcare Research, Brown University School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; Center for Long-Term Care Quality & Innovation, Brown University School of Public Health, Providence, RI, USA. Electronic address: ellen_mccreedy@brown.edu.
Anthony SistiDepartment of Biostatistics, Brown University School of Public Health, Providence, RI, USA.
Roee GutmanDepartment of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; Department of Biostatistics, Brown University School of Public Health, Providence, RI, USA.
Laura DionneCenter for Health Promotion and Health Equity, Brown University School of Public Health, Providence, RI, USA.
James L RudolphCenter for Gerontology & Healthcare Research, Brown University School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; US Department of Veterans Affairs Medical Center, Providence, RI, USA.
Rosa BaierCenter for Gerontology & Healthcare Research, Brown University School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; Center for Long-Term Care Quality & Innovation, Brown University School of Public Health, Providence, RI, USA.
Kali S ThomasCenter for Gerontology & Healthcare Research, Brown University School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; US Department of Veterans Affairs Medical Center, Providence, RI, USA.
Miranda B OlsonCenter for Long-Term Care Quality & Innovation, Brown University School of Public Health, Providence, RI, USA.
Esme E ZedikerCenter for Long-Term Care Quality & Innovation, Brown University School of Public Health, Providence, RI, USA.
Rebecca UthDepartment of Biostatistics, Brown University School of Public Health, Providence, RI, USA.
Renée R ShieldDepartment of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; Department of Biostatistics, Brown University School of Public Health, Providence, RI, USA.
Vincent MorCenter for Gerontology & Healthcare Research, Brown University School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; Center for Long-Term Care Quality & Innovation, Brown University School of Public Health, Providence, RI, USA; US Department of Veterans Affairs Medical Center, Providence, RI, USA.
Brown University · USUnited States Department of Veterans Affairs · US

Funding

METRIcAL - Music & MEmory: a Pragmatic TRIal for Nursing Home Residents with ALzheimer's DiseaseR33AG057451 · NIA · BROWN UNIVERSITY · PI MOR, VINCENT · 2018 to 2021
$5.0M
NIA NIH HHS R33 AG057451
6 · The paper itself

Abstract

objectiveTo test the effect of a personalized music intervention on agitated behaviors and medication use among long-stay nursing home residents with dementia.

designPragmatic, cluster-randomized controlled trial of a personalized music intervention. Staff in intervention facilities identified residents' early music preferences and offered music at early signs of agitation or when disruptive behaviors typically occur. Usual care in control facilities may include ambient or group music. SETTING AND

participantsThe study was conducted between June 2019 and February 2020 at 54 nursing homes (27 intervention and 27 control) in 10 states owned by 4 corporations.

methodsFour-month outcomes were measured for each resident. The primary outcome was frequency of agitated behaviors using the Cohen-Mansfield Agitation Inventory. Secondary outcomes included frequency of agitated behaviors reported in the Minimum Data Set and the proportion of residents using antipsychotic, antidepressant, or antianxiety medications.

resultsThe study included 976 residents with dementia [483 treatment and 493 control; mean age = 80.3 years (SD 12.3), 69% female, 25% African American]. CMAI scores were not significantly different (treatment: 50.67, SE 1.94; control: 49.34, SE 1.68) [average marginal effect (AME) 1.33, SE 1.38, 95% CI -1.37 to 4.03]. Minimum Data Set-based behavior scores were also not significantly different (treatment: 0.35, SE 0.13; control: 0.46, SE 0.11) (AME -0.11, SE 0.10, 95% CI -0.30 to 0.08). Fewer residents in intervention facilities used antipsychotics in the past week compared with controls (treatment: 26.2, SE 1.4; control: 29.6, SE 1.3) (AME -3.61, SE 1.85, 95% CI -7.22 to 0.00), but neither this nor other measures of psychotropic drug use were statistically significant. CONCLUSIONS AND IMPLICATIONS: Personalized music was not significantly effective in reducing agitated behaviors or psychotropic drug use among long-stay residents with dementia. Barriers to full implementation included engaging frontline nursing staff and identifying resident's preferred music.

Indexed as

Antipsychotic AgentsDementiaAged, 80 and overAntidepressive AgentsFemaleHumansMaleNursing HomesPsychomotor AgitationAntidepressive AgentsAntipsychotic Agentsagitated behaviorsantipsychoticsdementianeuropsychiatric symptomsnursing homesPragmatic randomized controlled trial

Identifiers

PMID35038407
PMCPMC9256757
OpenAlexW4206093661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.