Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile.
Article in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 4 institutions in 1 country.
Ping LiDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong, 510515, People's Republic of China.ORCID http://orcid.org/0000-0002-0047-376X
Shiqiang ChengSchool of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Yanta District, Xi'an, Shaanxi, 710061, People's Republic of China.ORCID http://orcid.org/0000-0001-8427-0312
Yan WenSchool of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Yanta District, Xi'an, Shaanxi, 710061, People's Republic of China.
Bolun ChengSchool of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Yanta District, Xi'an, Shaanxi, 710061, People's Republic of China.ORCID http://orcid.org/0000-0003-2915-5535
Li LiuSchool of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Yanta District, Xi'an, Shaanxi, 710061, People's Republic of China.ORCID http://orcid.org/0000-0003-0527-9250
Xiuhua WuDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong, 510515, People's Republic of China.
Xiang AoDepartment of Orthopaedics, the Third Affiliated Hospital of Southern Medical University, No.183, West Zhongshan Avenue, Tianhe District, Guangzhou, Guangdong, 510630, People's Republic of China.ORCID http://orcid.org/0000-0003-2568-8166
Zucheng HuangDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong, 510515, People's Republic of China.ORCID http://orcid.org/0000-0002-7086-7051
Congrui LiaoDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong, 510515, People's Republic of China.
Shaen LiDepartment of Outpatient, Air Force Hospital of Southern Theater Command, No. 801, East Dongfeng Avenue, Yuexiu District, Guangzhou, Guangdong, 510062, People's Republic of China.
Feng ZhangSchool of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Yanta District, Xi'an, Shaanxi, 710061, People's Republic of China. fzhxjtu@mail.xjtu.edu.cn.ORCID http://orcid.org/0000-0003-1339-5956
Zhongmin ZhangDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong, 510515, People's Republic of China. fzhxjtu@mail.xjtu.edu.cn.ORCID http://orcid.org/0000-0002-6761-6120
Nanfang Hospital · CNXi'an Jiaotong University · CNSouthern Medical University · CNThird Affiliated Hospital of Southern Medical University · CN
Funding
Fundamental Research Funds for the Central Universities xzy022019006National Natural Science Foundation of China 81922059
6 · The paper itself
Abstract
Amyotrophic lateral sclerosis, a fatal neurodegeneration disease affecting motor neurons in the brain and spinal cord, is difficult to diagnose and treat. The objective of this study is to identify novel candidate genes related to ALS. Transcriptome-wide association study of ALS was conducted by integrating the genome-wide association study summary data (including 1234 ALS patients and 2850 controls) and pre-computed gene expression weights of different tissues. The ALS-associated genes identified by TWAS were further compared with the differentially expressed genes detected by the mRNA expression profiles of the sporadic ALS. Functional enrichment and annotation analysis of identified genes were performed by an R package and the functional mapping and annotation software. TWAS identified 761 significant genes (P
Indexed as
Amyotrophic Lateral SclerosisTranscriptomeGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansQuantitative Trait LociRNA, MessengerRNA, MessengerAmyotrophic lateral sclerosis (ALS)mRNA expression profileSporadic Amyotrophic lateral sclerosis (sALS)Transcriptome-wide association study (TWAS)
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile. · full record | OpenQuestion