Evidence map›Paper›PMID 35037817›Full record

ArticleInhalation toxicology

Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice.

Tamara L Young, David Scieszka, Jessica G Begay, Selita N Lucas, Guy Herbert, Katherine Zychowski, Russell Hunter, Raul Salazar, Andrew K Ottens, Aaron Erdely and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inhalation toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Tamara L YoungDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.
David ScieszkaDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.
Jessica G BegayDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.
Selita N LucasDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.
Guy HerbertDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.
Katherine ZychowskiCollege of Nursing, University of New Mexico, Albuquerque, NM, USA.ORCID 0000-0002-5751-2897
Russell HunterDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.
Raul SalazarDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.
Andrew K OttensDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA.
Aaron ErdelyPathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Haiwei GuCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Matthew J CampenDepartment of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA.ORCID 0000-0002-2292-5050
University of New Mexico · USFlorida International University · USNational Institute for Occupational Safety and Health · USVirginia Commonwealth University · US

Funding

University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Matthew J Campen · 2020 to 2026
$20.4M
Mechanisms of Vascular Toxicity from Inhaled ToxicantsR01ES014639 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J · 2008 to 2023
$6.7M
Systemic Health Implications of Occupational Nanomaterial ExposureR01OH010828 · OH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, OTTENS, ANDREW K · 2015 to 2018
$1.9M
NIEHS NIH HHS R01 ES014639NIGMS NIH HHS P20 GM130422NIOSH CDC HHS R01 OH010828
6 · The paper itself

Abstract

objectiveEnvironmental exposures exacerbate age-related pathologies, such as cardiovascular and neurodegenerative diseases. Nanoparticulates, and specifically carbon nanomaterials, are a fast-growing contributor to the category of inhalable pollutants, whose risks to health are only now being unraveled. The current study assessed the exacerbating effect of age on multiwalled-carbon nanotube (MWCNT) exposure in young and old C57BL/6 and ApoE MATERIALS AND

methodsFemale C57BL/6 and apolipoprotein E-deficient (ApoE

resultsPulmonary neutrophil infiltration was induced by MWCNT in bronchoalveolar lavage fluid in both C57BL/6 and ApoE

conclusionsAge influences the pulmonary and neurological responses to short-term MWCNT exposure. However, with only the model of moderate aging (15 months) in this study, the responses appeared modest compared to inhaled toxicant impacts in more advanced aging models.

Indexed as

Nanotubes, CarbonAnimalsApolipoproteinsApolipoproteins EBronchoalveolar Lavage FluidFemaleInflammationInhalation ExposureLungMiceMice, Inbred C57BLApolipoproteinsApolipoproteins ENanotubes, CarbonagingApoEcarbon nanotubesinflammationMWCNTnanoparticlesneuroinflammation

Identifiers

PMID35037817
PMCPMC10037439
OpenAlexW4206748317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.