ArticleEnvironmental health perspectives2022
Associations of Childhood and Perinatal Blood Metals with Children's Gut Microbiomes in a Canadian Gestation Cohort.
Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Changes in Prooxidant and Antioxidant-Related Trace Element Levels During Helicobacter pylori Eradication Therapy.Biological trace element research · 2026Article
- Population-Level Amplicon and Metagenomic Analyses Uncover Distinct Effects of Landscape-Level Pesticides on the Maternal Gut Microbiome.Environment & health (Washington, D.C.) · 2026Article
- Associations Between Blood Metal Exposure and Hypertriglyceridemia Among Adults in NHANES, 2011-2018.Food science & nutrition · 2025Article
- Lead exposure in relation to gut homeostasis, microbiota, and metabolites.Applied and environmental microbiology · 2025Review
- Article
- The role of the gut microbiome in the associations between lead exposure and child neurodevelopment.Toxicology letters · 2025Review
- Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study.Genome medicine · 2025Article
- Trace Element Exposure during Pregnancy Has a Persistent Influence on Perinatal Gut Microbiota in Mother-Infant Dyads.Environmental science & technology · 2025Article
- Metabolic pathways associated with Firmicutes prevalence in the gut of multiple livestock animals and humans.Animal microbiome · 2025Article
- Association between infants' serum levels of 26 metals and gut microbiota: a hospital-based cross-sectional study in China.Frontiers in microbiology · 2025Article
- Article
- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- Prenatal metal exposures and childhood gut microbial signatures are associated with depression score in late childhood.The Science of the total environment · 2024Article
- Exposure to Environmental Pollutants and Risk of Diarrhea: A Systematic Review.Environmental health insights · 2024Review
- Toxic and essential metals: metabolic interactions with the gut microbiota and health implications.Frontiers in nutrition · 2024Review
- Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA).Environmental science & technology · 2023Article
- Prenatal Pb exposure is associated with reduced abundance of beneficial gut microbial cliques in late childhood: an investigation using Microbial Co-occurrence Analysis (MiCA).medRxiv : the preprint server for health sciences · 2023Article
- Prenatal Lead Exposure is Negatively Associated with the Gut Microbiome in Childhood.medRxiv : the preprint server for health sciences · 2023Article
- Influence of perinatal and childhood exposure to tobacco and mercury in children's gut microbiota.Frontiers in microbiology · 2023Article
- Prenatal lead exposure is negatively associated with the gut microbiome in childhood.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundThe gut microbiome is important in modulating health in childhood. Metal exposures affect multiple health outcomes, but their ability to modify bacterial communities in children is poorly understood.
objectivesWe assessed the associations of childhood and perinatal blood metal levels with childhood gut microbiome diversity, structure, species, gene family-inferred species, and potential pathway alterations.
methodsWe assessed the gut microbiome using 16S rRNA gene amplicon sequencing and shotgun metagenomic sequencing in stools collected from 6- to 7-year-old children participating in the GESTation and Environment (GESTE) cohort study. We assessed blood metal concentrations [cadmium (Cd), manganese (Mn), mercury (Hg), lead (Pb), selenium (Se)] at two time points, namely, perinatal exposures at delivery (
resultsChildren's blood Mn and Se significantly associated with microbiome phylum [e.g., Verrucomicrobiota ( DISCUSSION: Our findings suggest both long- and short-term associations between metal exposure and the childhood gut microbiome, with stronger associations observed with more recent exposure. Future epidemiologic analyses may elucidate whether the observed changes in the microbiome relate to children's health. https://doi.org/10.1289/EHP9674.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.