Evidence map›Paper›PMID 35037617›Full record

ArticleMicrobial genomics2022

regentrans: a framework and R package for using genomics to study regional pathogen transmission.

Sophie Hoffman, Zena Lapp, Joyce Wang, Evan S Snitkin

Abstract readMulticenter Study
In one paragraph

Article in Microbial genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Genomic analysis ofMicrobial genomics · 2025
    Article
  4. Article
  5. Distinct Origins and Transmission Pathways ofJournal of clinical microbiology · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sophie HoffmanDepartment of Computational Medicine and Bioinformatics, University of Michigan, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109-5680, USA.
Zena LappDepartment of Computational Medicine and Bioinformatics, University of Michigan, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109-5680, USA.
Joyce WangDepartment of Microbiology and Immunology, University of Michigan, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109-5680, USA.
Evan S SnitkinDepartment of Microbiology and Immunology, University of Michigan, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109-5680, USA.

Funding

University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Regional genomic epidemiology to identify drivers of resistance, transmission and infection with carbapenem-resistant Klebsiella pneumoniaeR01AI148259 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SNITKIN, EVAN · 2020 to 2023
$2.2M
CIHRNHGRI NIH HHS T32 HG000040NIAID NIH HHS R01 AI148259
6 · The paper itself

Abstract

Increasing evidence of regional pathogen transmission networks highlights the importance of investigating the dissemination of multidrug-resistant organisms (MDROs) across a region to identify where transmission is occurring and how pathogens move across regions. We developed a framework for investigating MDRO regional transmission dynamics using whole-genome sequencing data and created regentrans, an easy-to-use, open source R package that implements these methods (https://github.com/Snitkin-Lab-Umich/regentrans). Using a dataset of over 400 carbapenem-resistant isolates of

Indexed as

Drug Resistance, Multiple, BacterialCarbapenemsCross InfectionDatabases, GeneticGenomicsHumansKlebsiella InfectionsKlebsiella pneumoniaePhylogenySoftwareWhole Genome SequencingCarbapenemsgenomicspathogen spreadregional transmissionR packagesoftwarewhole genome sequencing

Identifiers

PMID35037617
PMCPMC8914358

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.