Evidence map›Paper›PMID 35037462›Full record

ArticleACS infectious diseases2022

Development of Inhibitors of SAICAR Synthetase (PurC) from

Sitthivut Charoensutthivarakul, Sherine E Thomas, Amy Curran, Karen P Brown, Juan M Belardinelli, Andrew J Whitehouse, Marta Acebrón-García-de-Eulate, Jaspar Sangan, Subramanian G Gramani, Mary Jackson and 5 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A journey into the regulatory secrets of theFrontiers in pharmacology · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Ethyl Acetate Fraction ofAntibiotics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Sitthivut CharoensutthivarakulYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0002-4447-3438
Sherine E ThomasDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.
Amy CurranYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Karen P BrownMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.
Juan M BelardinelliMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States.
Andrew J WhitehouseYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Marta Acebrón-García-de-EulateDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.ORCID 0000-0002-6035-7525
Jaspar SanganMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.
Subramanian G GramaniYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0002-8536-756X
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States.ORCID 0000-0002-9212-0258
Vitor MendesDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.ORCID 0000-0002-2734-2444
R Andres FlotoMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.
Tom L BlundellDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.
Anthony G CoyneYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0003-0205-5630
Chris AbellYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0001-9174-1987
University of Cambridge · GBMRC Laboratory of Molecular Biology · GBColorado State University · US

Funding

Wellcome Trust 107032Wellcome Trust 200814/Z/16/ZWellcome Trust 200814_Z_16_ZWellcome Trust I07032AIA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mycobacterium abscessusAnti-Bacterial AgentsCrystallography, X-RayHumansPeptide SynthasesAnti-Bacterial AgentsPeptide Synthasesphosphoribosylaminoimidazole-succinocarboxamide synthetasecystic fibrosisfragment-based drug discoveryMycobacterium abscessusPurCSAICAR synthetasestructure-guided

Identifiers

PMID35037462
PMCPMC7614835
OpenAlexW4206506189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.