ArticleClinical and translational science2022
Facilitators and barriers to pediatric clinical trial recruitment and retention in rural and community settings: A scoping review of the literature.
Article in Clinical and translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Effective and cost-effective strategies for recruiting rural adults into a civic engagement and health behavior change research study.BMC public health · 2026Trial
- Mental health outcomes of a pediatric-focused obesity randomized control trial in rural communities.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Trial
- Active vs Traditional Methods of Recruiting Children for a Clinical Trial in Rural Primary Care Clinics: A Cluster-Randomized Clinical Trial.JAMA network open · 2022Trial
- Expedited research and approval of medicines for drug-resistant bacterial infections in children.Bulletin of the World Health Organization · 2026Article
- Parental perspectives and willingness towards digital paediatric research: a cross-sectional survey in two Chinese cities.BMJ open · 2026Article
- Reach and representativeness within a rural randomized controlled trial designed to improve community health through civic engagement for built environment change in Texas and New York.Wellbeing, space and society · 2026Article
- A national strategic framework for developing medical devices for children.Pediatric research · 2026Article
- Mobile Vaccine Uptake (MoVeUP): a randomized effectiveness trial for a vaccine communication app.Vaccine: X · 2026Article
- Designing communication strategies to increase rural participation in clinical trials using the Health Belief Model and strategic communication.Contemporary clinical trials communications · 2026Article
- A Survey Study of Roadblocks in Translational Science.Clinical and translational science · 2025Article
- A Pharmacokinetic Study of Zavegepant Nasal Spray in Healthy Adults Comparing Conventional Venous Blood Sampling With Patient-Centric Microsampling.Clinical and translational science · 2025Article
- Understanding the influence of social determinants of health on symptom reporting in pediatric cancer.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Deconstructing rurality to better "place" health data.International journal of geographical information science : IJGIS · 2025Article
- Navigating challenges in pediatric trial conduct: integrating bayesian sequential design with semiparametric elicitation for handling primary and secondary endpoints.BMC medical research methodology · 2025Article
- The Importance of Including Underserved Populations in Research.Pharmaceutical medicine · 2025Review
- Urban-Suburban Differences in Public Perspectives on Digitalizing Pediatric Research: Cross-Sectional Survey Study.Journal of medical Internet research · 2025Article
- Presence of Institutional Guidance on Research-Related Transportation Could Help Reduce Barriers to and Disparities in Research Engagement.Journal of clinical and translational science · 2025Article
- Article
- Efforts to Enhance Recruitment and Engagement of Caregivers from Medically Underserved Communities in a Randomized Controlled Trial of a Vaccine Promotion App.Journal of clinical and translational science · 2025Article
- Development of clinical research networks in rural America: Our experience from the Accelerating COVID-19 Therapeutic Interventions and Vaccines-1 trialau.Journal of clinical and translational science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Children in rural settings are under-represented in clinical trials, potentially contributing to rural health disparities. We performed a scoping review describing available literature on barriers and facilitators impacting participation in pediatric clinical trials in rural and community-based (nonclinical) settings. Articles identified via PubMed, CINAHL, Embase, and Web of Science were independently double-screened at title/abstract and full-text levels to identify articles meeting eligibility criteria. Included articles reported on recruitment or retention activities for US-based pediatric clinical studies conducted in rural or community-based settings and were published in English through January 2021. Twenty-seven articles describing 31 studies met inclusion criteria. Most articles reported on at least one study conducted in an urban or suburban or unspecified community setting (n = 23 articles; 85%); fewer (n = 10; 37%) reported on studies that spanned urban and rural settings or were set in rural areas. More studies discussed recruitment facilitators (n = 25 studies; 81%) and barriers (n = 19; 61%) versus retention facilitators (n = 15; 48%) and barriers (n = 8; 26%). Descriptions of recruitment and retention barriers and facilitators were primarily experiential or subjective. Recruitment and retention facilitators were similar across settings and included contacts/reminders, community engagement, and relationship-building, consideration of participant logistics, and incentives. Inadequate staff and resources were commonly cited recruitment and retention barriers. Few studies have rigorously examined optimal ways to recruit and retain rural participants in pediatric clinical trials. To expand the evidence base, future studies examining recruitment and retention strategies should systematically assess and report rurality and objectively compare relative impact of different strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.