Evidence map›Paper›PMID 35037098›Full record

ArticleAmino acids2022

An efficient synthesis of cis-4-hydroxyphosphonic and cis-4-hydroxyphosphinic analogs of pipecolic acid from cyclic enaminones.

Rubén Oswaldo Argüello-Velasco, Juan Carlos Morales-Solís, Misael Muñoz-Vidales, José Luis Viveros-Ceballos, Ivan Romero-Estudillo, Mario Ordóñez

Abstract read
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In one paragraph

Article in Amino acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rubén Oswaldo Argüello-VelascoCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209, Cuernavaca, Morelos, Mexico.ORCID http://orcid.org/0000-0002-1729-0994
Juan Carlos Morales-SolísCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209, Cuernavaca, Morelos, Mexico.ORCID http://orcid.org/0000-0002-1996-4729
Misael Muñoz-VidalesCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209, Cuernavaca, Morelos, Mexico.
José Luis Viveros-CeballosCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209, Cuernavaca, Morelos, Mexico.ORCID http://orcid.org/0000-0003-0202-4180
Ivan Romero-EstudilloCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209, Cuernavaca, Morelos, Mexico.ORCID http://orcid.org/0000-0003-3924-3598
Mario OrdóñezCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209, Cuernavaca, Morelos, Mexico. palacios@uaem.mx.ORCID http://orcid.org/0000-0001-9395-7079

Funding

Consejo Nacional de Ciencia y Tecnología 140607Consejo Nacional de Ciencia y Tecnología 286614
6 · The paper itself

Abstract

An expedient synthetic entry to cis-4-hydroxyphosphonic and cis-4-hydroxyphosphinic analogs of cis-4-hydroxypipecolic acid is presented in this paper. The main feature of this methodology is the highly regioselective addition of silyl phosphites or phosphonites to cyclic 1-benzyloxycarbonyl enaminones. Interestingly, the hydride reduction of the resulting 2-phospho-4-oxopiperidine proceeds with high diastereofacial preference using NaBH

Indexed as

OrganophosphonatesPipecolic AcidsHydrolysisOrganophosphonatesPipecolic AcidsCis-4-hydroxyphosphopipecolic acidsCyclic enaminonesCyclic α-aminophosphinic acidsCyclic α-aminophosphonic acidsDiastereoselective reduction

Identifiers

PMID35037098

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.