ArticleNature cardiovascular research2022
Circadian REV-ERBs repress
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Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 64 citations in OpenAlex.
- Circadian mechanisms in heart failure: Cell-specific regulation and chrono-medicine.Cell insight · 2026Review
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- Type 1 diabetes differentially disrupts right and left ventricular daily rhythms.Function (Oxford, England) · 2026Article
- Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms.Circulation research · 2026Review
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- NADCommunications biology · 2026Article
- Multilayer Timing of Cardiac Circadian Regulation Informs Prevention and Treatment of Cardiovascular Disease.Vascular health and risk management · 2026Article
- Beyond Leptin and Adiponectin: The Diverse Roles of Adipokines in the Myocardial Hypertrophic Process and Heart Failure and Their Potential Contribution in Obesity.International journal of molecular sciences · 2025Review
- Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time.Life metabolism · 2025Review
- Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity.Cardiovascular research · 2025Review
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- REV-ERBα regulates brain NADNature aging · 2025Article
- Boosting astrocytic NADNature aging · 2025Article
- Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt.Nature immunology · 2025Article
- Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.Signal transduction and targeted therapy · 2025Review
- Role of circadian rhythms in heart failure: insights from myocardial energy metabolism.Journal of translational medicine · 2025Review
- BMAL1 in Ischemic Heart Disease: A Narrative Review from Molecular Clock to Myocardial Pathology.International journal of molecular sciences · 2025Review
- The metabolic significance of peripheral tissue clocks.Communications biology · 2025Review
- The Core Circadian Clock Factor, Bmal1, Transduces Sex-specific Differences in Both Rhythmic and Nonrhythmic Gene Expression in the Mouse Heart.Function (Oxford, England) · 2025Article
- BMAL1 is a Critical Regulator of Sex-Specific Gene Expression in the Heart.Function (Oxford, England) · 2025Article
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Authors and funding
22 authors at 5 institutions in 1 country.
Pieterjan DierickxInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Kun ZhuInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Bryce J CarpenterInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Chunjie JiangInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Marit W VermuntDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Yang XiaoInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Timothy S LuongoInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Tsunehisa YamamotoCardiovascular Institute and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Íngrid Martí-PàmiesCardiovascular Institute and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sobuj MiaDivision of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35226, United States.
Mary LatimerDivision of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35226, United States.
Abhinav DiwanDivision of Cardiology, Washington University School of Medicine, St. Louis, MO, United States.
Juanjuan ZhaoCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Amy K HauckInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Brianna KrusenInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Hoang C B NguyenInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Gerd A BlobelDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Daniel P KellyInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Liming PeiInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Joseph A BaurInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Martin E YoungDivision of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35226, United States.
Mitchell A LazarInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USUniversity of Alabama at Birmingham · USCardiovascular Institute of the South · USWashington University in St. Louis · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MUniversity of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5MREV-ERB Nuclear Receptors in Circadian Rhythm and MetabolismR01DK045586 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1992 to 2026
$12.0MREGULATION OF FATTY ACID OXIDATION DURING CARDIAC GROWTHR01HL058493 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1998 to 2024
$10.6MProbing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1MTargeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1MROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9MTargeting Ketone Metabolism as a Novel Heart Failure TherapyR01HL151345 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KELLY, DANIEL PATRICK, RECCHIA, FABIO A · 2020 to 2023
$3.2MUnderstanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failureR01HL165792 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2022 to 2025
$2.7MMaternal obesity and cardiometabolic health in the offspringR01HL143431 · NHLBI · WASHINGTON UNIVERSITY · PI DIWAN, ABHINAV · 2018 to 2021
$2.5MCoordinated regulation of mitochondrial and cellular functions by nuclear receptorsR01DK111495 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PEI, LIMING · 2017 to 2021
$2.0MNHLBI NIH HHS F32 HL145923NHLBI NIH HHS R01 HL058493NHLBI NIH HHS R01 HL107594NHLBI NIH HHS R01 HL128349NHLBI NIH HHS R01 HL143431NHLBI NIH HHS R01 HL149159NHLBI NIH HHS R01 HL151345NHLBI NIH HHS R01 HL165792NIDDK NIH HHS F32 DK122684NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK045586NIDDK NIH HHS R01 DK098656NIDDK NIH HHS R01 DK111495
Abstract
The heart is a highly metabolic organ that uses multiple energy sources to meet its demand for ATP production. Diurnal feeding-fasting cycles result in substrate availability fluctuations which, together with increased energetic demand during the active period, impose a need for rhythmic cardiac metabolism. The nuclear receptors REV-ERBα and β are essential repressive components of the molecular circadian clock and major regulators of metabolism. To investigate their role in the heart, here we generated mice with cardiomyocyte (CM)-specific deletion of both
Indexed as
Circadian RhythmCytokinesMyocytes, CardiacNADNicotinamide PhosphoribosyltransferaseNuclear Receptor Subfamily 1, Group D, Member 1AnimalsBasic-Leucine Zipper Transcription FactorsCells, CulturedCircadian ClocksGene Expression RegulationMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, Cytoplasmic and NuclearBasic-Leucine Zipper Transcription FactorsCytokinesNADNfil3 protein, mouseNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseNr1d1 protein, mouseNr1d2 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1Receptors, Cytoplasmic and NuclearRepressor Proteins
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