ArticleThe Lancet regional health. Western Pacific2022
Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study.
Article in The Lancet regional health. Western Pacific, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Sex differences in bacterial meningitis and associations with socioeconomic indicators: a systematic review and meta-analysis with metaregression.BMJ global health · 2025Pooled it
- Prevalence of Japanese encephalitis in pigs in Mainland China during 2000-2024: a systemic review and meta-analysis.Frontiers in veterinary science · 2025Pooled it
- Clinical and laboratory profiles of acute central nervous system infections in a Chinese pediatric cohort: a five-year retrospective analysis.BMC pediatrics · 2026Article
- Nationwide Analysis of In-Hospital Mortality in Patients with Encephalitis-Related Diagnoses in Ecuador.Diseases (Basel, Switzerland) · 2026Article
- Strengthening preparedness and response to emerging henipavirus diversity.Frontiers in cellular and infection microbiology · 2026Review
- [Infectious and inflammatory diseases of the central nervous system 2014-2024].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Pathogen profiles in CSF from patients with acute infectious meningitis or encephalitis: a multicenter study based on multiplex PCR and mNGS in China, 2018-2019.BMC infectious diseases · 2025Article
- The conserved transcription factor PrlP modulates colonization and pathogenicity of Streptococcus suis in response to environmental stress.PLoS pathogens · 2025Article
- Novel Perspectives Focused on the Relationship Between Herpesvirus Encephalitis and Anti-GFAP-Antibody-Positive Astrocytopathy.Molecular neurobiology · 2025Review
- Epidemiological Features, Clinical Symptoms, and Environmental Risk Factors for Notifiable Japanese Encephalitis in Taiwan From 2008 to 2020: Retrospective Study.JMIR public health and surveillance · 2025Article
- Analysis of the trends in burden of meningitis in China from 1990 to 2021, and projections until 2036.Frontiers in public health · 2025Article
- Real-world safety profile of live attenuated Japanese encephalitis vaccine before and after the vaccine administration law.PloS one · 2025Article
- Exploring the appropriate situation of performing CSF mNGS in patients with proposed intracranial infections.BMC neurology · 2024Article
- Epidemiology of autoimmune encephalitis and comparison to infectious causes-Experience from a tertiary center.Annals of clinical and translational neurology · 2024Article
- Determining the bacterial and viral meningitis trend in Iraq from 2007 till 2023 using joinpoint regression.Heliyon · 2024Article
- Metagenomic next-generation sequencing of cell-free DNA for the identification of viruses causing central nervous system infections.Microbiology spectrum · 2024Article
- Investigation of the association between circulating inflammatory proteins and encephalitis risk in Europeans by two-sample Mendelian randomization analysis.Frontiers in neurology · 2024Article
- Metagenomic next-generation sequencing of cerebrospinal fluid: a diagnostic approach for varicella zoster virus-related encephalitis.Frontiers in cellular and infection microbiology · 2024Article
- Disease Burden of Meningitis Caused by Streptococcus pneumoniae Among Under-Fives in China: A Systematic Review and Meta-analysis.Infectious diseases and therapy · 2023Review
- Tackling a global epidemic threat: Nipah surveillance in Bangladesh, 2006-2021.PLoS neglected tropical diseases · 2023Article
Corrections and comments
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Authors and funding
39 authors at 13 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute meningitis or encephalitis (AME) results from a neurological infection causing high case fatality and severe sequelae. AME lacked comprehensive surveillance in China.
methodsNation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods.
findingsBetween 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 patients with all-four-virus tested, 28.43% (95% CI: 27.50%‒29.36%) of them had at least one virus-positive detection. Enterovirus was the most frequently determined virus in children <18 years, herpes simplex virus and Japanese encephalitis virus were the most frequently determined in 18-59 and ≥60 years age groups, respectively. Based on 6,802 patients with all-seven-bacteria tested, 4.43% (95% CI: 3.94%‒4.91%) had at least one bacteria-positive detection,
interpretationThe current findings allow enhanced identification of the predominant AME-related pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures in China, and a possible reassessment of vaccination strategy.
fundingChina Mega-Project on Infectious Disease Prevention and the National Natural Science Funds.
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