ArticleNature aging2021
Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models.
Open access · greenAbstract read
In one paragraph
Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
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- Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases.Nature reviews. Molecular cell biology · 2024Review
- Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors.International journal of molecular sciences · 2024Review
Corrections and comments
- Commented on by
Authors and funding
15 authors at 2 institutions in 1 country.
Hong Seok ShimDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
James W HornerInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Chang-Jiun WuDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Jiexi LiDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Zheng D LanDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Shan JiangInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Xueping XuInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Wen-Hao HsuDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Tomasz ZalDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Ivonne I FloresInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Pingna DengDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Yuan-Ta LinPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Li-Huei TsaiPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Y Alan WangDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Ronald A DePinhoDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
The University of Texas MD Anderson Cancer Center · USMassachusetts Institute of Technology · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MTELOMERASE IN DEVELOPMENT, SENESCENCE AND NEOPLASIAR01CA084628 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2000 to 2019
$10.5MDeveloping Novel Therapeutic Approaches Targeting Macrophages in GBMR01CA231349 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WANG, Y. ALAN · 2019 to 2024
$1.8MSuper-Resolution OMX MicroscropeS10RR029552 · NCRR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ZAL, TOMASZ · 2011 to 2011
$1.0MNCI NIH HHS P30 CA016672NCI NIH HHS R01 CA084628NCI NIH HHS R01 CA231349NCRR NIH HHS S10 RR029552
Abstract
Amyloid-induced neurodegeneration plays a central role in Alzheimer's disease (AD) pathogenesis. Here, we show that
Indexed as
Alzheimer DiseaseTelomeraseAmyloid beta-PeptidesAnimalsCognitionHumansMiceNeuronsAmyloid beta-PeptidesTelomerase
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.