Evidence map›Paper›PMID 35036869›Full record

ArticleiScience2022

Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation.

Nhu Nguyen, Kristbjorn O Gudmundsson, Anthony R Soltis, Kevin Oakley, Kartik R Roy, Yufen Han, Carmelo Gurnari, Jaroslaw P Maciejewski, Gary Crouch, Patricia Ernst and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. MYB as a Critical Transcription Factor and Potential Therapeutic Target in AML.Advances in experimental medicine and biology · 2024
    Review
  3. An enhancer RNA recruits MLL1 to regulate transcription ofbioRxiv : the preprint server for biology · 2023
    Article
  4. Article
  5. Article
  6. The impact of SETBP1 mutations in neurological diseases and cancer.Genes to cells : devoted to molecular & cellular mechanisms · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Nhu NguyenDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Kristbjorn O GudmundssonDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Anthony R SoltisThe American Genome Center (TAGC), Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Kevin OakleyDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Kartik R RoyDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Yufen HanDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Carmelo GurnariDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Jaroslaw P MaciejewskiDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Gary CrouchDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.
Patricia ErnstDepartment of Pediatrics, Section of Hematology/Oncology/BMT, University of Colorado, Denver/Anschutz Medical Campus, Aurora, CO 80045, USA.
Clifton L DalgardThe American Genome Center (TAGC), Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Yang DuDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Uniformed Services University of the Health Sciences · USCleveland Clinic · USIcahn School of Medicine at Mount Sinai · USUniversity of Colorado Anschutz Medical Campus · US

Funding

MLL Family Histone Methyltransferases in Myeloid LeukemiaR01CA224436 · NCI · UNIVERSITY OF COLORADO DENVER · PI ERNST, PATRICIA · 2018 to 2022
$2.1M
Role of Setbp1 in leukemic stem cell self-renewalR01CA143193 · NCI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI DU, YANG · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA143193NCI NIH HHS R01 CA224436
6 · The paper itself

Abstract

Abnormal activation of

Indexed as

Biological sciencesCancerCell biologyMolecular biology

Identifiers

PMID35036869
PMCPMC8749219
OpenAlexW4226058079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.