Evidence map›Paper›PMID 35036684›Full record

ArticleACS omega2022

Altering the Double-Stranded DNA Specificity of the bZIP Domain of Zta with Site-Directed Mutagenesis at N182.

Sreejana Ray, Desiree Tillo, Nima Assad, Aniekanabasi Ufot, Aleksey Porollo, Stewart R Durell, Charles Vinson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sreejana RayLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Room 5000, Building 37, Bethesda, Maryland 20892, United States.ORCID https://orcid.org/0000-0002-1955-1131
Desiree TilloLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Room 5000, Building 37, Bethesda, Maryland 20892, United States.ORCID https://orcid.org/0000-0003-3568-6148
Nima AssadLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Room 5000, Building 37, Bethesda, Maryland 20892, United States.
Aniekanabasi UfotLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Room 5000, Building 37, Bethesda, Maryland 20892, United States.
Aleksey PorolloCenter for Autoimmune Genomics and Etiology, Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, United States.
Stewart R DurellLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Bethesda, Maryland 20892, United States.ORCID https://orcid.org/0000-0002-7806-0359
Charles VinsonLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Room 5000, Building 37, Bethesda, Maryland 20892, United States.ORCID https://orcid.org/0000-0002-3708-7416
National Institutes of Health · USCincinnati Children's Hospital Medical Center · US

Funding

Effects of Cytosine Modifications on Transcription Factor BindingZICBC011724 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DURELL, STEWART · 2016 to 2023
$961k
6 · The paper itself

Abstract

Zta, the Epstein-Barr virus bZIP transcription factor (TF), binds both unmethylated and methylated double-stranded DNA (dsDNA) in a sequence-specific manner. We studied the contribution of a conserved asparagine (N182) to sequence-specific dsDNA binding to four types of dsDNA: (i) dsDNA with cytosine in both strands ((DNA(C|C)), (ii, iii) dsDNA with 5-methylcytosine (5mC,

Identifiers

PMID35036684
PMCPMC8756438
OpenAlexW4200408810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.