ArticleLearning health systems2022
Developing real-world evidence from real-world data: Transforming raw data into analytical datasets.
Article in Learning health systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity.BMC medical research methodology · 2023Pooled it
- Computable phenotypes for research using real-world data: experiences from the NIH pragmatic trials collaboratory.JAMIA open · 2026Article
- Distinct Patterns of Mobility Recovery After Stroke Using Routine Clinical Data.medRxiv : the preprint server for health sciences · 2026Article
- Extending the Fundamental Theorem of Biomedical Informatics for the AI era.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Potential for Bias in Social Needs Data Collection and Screening Activities in Health Care Settings.JAMA health forum · 2026Article
- Conformal selective prediction with cost aware deferral for safe clinical triage under distribution shift.Scientific reports · 2026Article
- An Onset Detection Method for Slowly Activated Muscle Based on Marginal Spectrum Entropy.Sensors (Basel, Switzerland) · 2025Article
- Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study.Journal of medical Internet research · 2025Article
- MISTIC: a novel approach for metastasis classification in Italian electronic health records using transformers.BMC medical informatics and decision making · 2025Article
- Assessing the harmonization of structured electronic health record data to reference terminologies and data completeness through data provenance.Learning health systems · 2025Article
- Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative.Journal of medical Internet research · 2025Article
- Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024).JMIR public health and surveillance · 2025Article
- Five-year dementia prediction and decision support system based on real-world data.Frontiers in aging neuroscience · 2025Article
- A SARS-CoV-2 minimum data standard to support national serology reporting.Annals of clinical biochemistry · 2024Article
- Predictive Modeling of Drug-Related Adverse Events with Real-World Data: A Case Study of Linezolid Hematologic Outcomes.Clinical pharmacology and therapeutics · 2024Article
- Article
- Use of Healthcare Claims Data to Generate Real-World Evidence on Patients With Drug-Resistant Epilepsy: Practical Considerations for Research.Journal of health economics and outcomes research · 2024Article
- Linking Patient Encounters across Primary and Ancillary Electronic Health Record Systems: A Comparison of Two Approaches.ACI open · 2024Article
- Phenotypic presentation of Mendelian disease across the diagnostic trajectory in electronic health records.Genetics in medicine : official journal of the American College of Medical Genetics · 2023Article
- Healthcare utilization is a collider: an introduction to collider bias in EHR data reuse.Journal of the American Medical Informatics Association : JAMIA · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Development of evidence-based practice requires practice-based evidence, which can be acquired through analysis of real-world data from electronic health records (EHRs). The EHR contains volumes of information about patients-physical measurements, diagnoses, exposures, and markers of health behavior-that can be used to create algorithms for risk stratification or to gain insight into associations between exposures, interventions, and outcomes. But to transform real-world data into reliable real-world evidence, one must not only choose the correct analytical methods but also have an understanding of the quality, detail, provenance, and organization of the underlying source data and address the differences in these characteristics across sites when conducting analyses that span institutions. This manuscript explores the idiosyncrasies inherent in the capture, formatting, and standardization of EHR data and discusses the clinical domain and informatics competencies required to transform the raw clinical, real-world data into high-quality, fit-for-purpose analytical data sets used to generate real-world evidence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.