Evidence map›Paper›PMID 35036312›Full record

ReviewJournal of clinical orthopaedics and trauma2022

The role of Platelet Rich Plasma and other orthobiologics in bone healing and fracture management: A systematic review.

M S Jamal, E T Hurley, H Asad, A Asad, T Taneja

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical orthopaedics and trauma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Technology behind augmenting fracture healing.Bulletin of the Hospital for Joint Disease (2013) · 2025
    Review
  6. Avoiding Hallux Sesamoidectomy: A Narrative Review.Journal of clinical medicine · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Advances with Platelet-Rich Plasma for Bone Healing.Biologics : targets & therapy · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M S JamalBlizzard Institute, Barts and the London School of Medicine & Dentistry, London, UK.
E T HurleyDepartment of Trauma & Orthopaedic Surgery, NYU Langone Health, New York, USA.
H AsadBlizzard Institute, Barts and the London School of Medicine & Dentistry, London, UK.
A AsadBlizzard Institute, Barts and the London School of Medicine & Dentistry, London, UK.
T TanejaBlizzard Institute, Barts and the London School of Medicine & Dentistry, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment of large bone defects and fracture healing complications (delayed and non-union) presents a substantial challenge for orthopaedic surgeons. Given that bone healing requires mechanical stability as well as a favourable biological microenvironment, orthobiologics such as Platelet-Rich Plasma (PRP) may have a significant clinical role to play.

aimsTo perform a systematic review of the available literature to assess the clinical effect of PRP, with or without other orthobiologics, on bone healing.

methodTwo independent reviewers performed the literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Clinical studies of any evidence, assessing effect of PRP with or without other orthobiologics on bone healing, were included. A qualitative analysis was carried out on the clinical and radiological outcomes reported.

result27 articles with 1631 patients (mean age = 43.56, 57.1% male, mean follow-up = 17.27 months) were included in the qualitative. Of the 27 studies, 13 dealt with fracture complications (delayed or non-unions), 7 with acute fracture healing, 4 with tibial osteotomies and lengthening procedures and 3 with lumbar spine pathology. 18/27 studies showed a clinical benefit of PRP, 8/27 showed no significant effect, and 1/27 showed a worse outcome with PRP.

conclusionOur review suggests PRP may play a clinical role in bone healing but further randomised controlled trials (RCTs) using standardised outcomes should be performed to establish its efficacy.

Indexed as

Delayed unionFracture healingNon-unionOrthobiologicPlatelet-rich plasmaPRP

Identifiers

PMID35036312
PMCPMC8749440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.