Evidence map›Paper›PMID 35036304›Full record

ArticleRespiratory medicine case reports2022

Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report.

Haruyasu Sakuranaka, Takashi Nakagawa, Shun Yokota, Eichi Takahashi, Yuji Yamakawa, Akifumi Hirata, Koumei Igei, Naoki Okamoto, Masahiko Ichioka

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Haruyasu SakuranakaDepartment of Respiratory Medicine, Toshima Hospital, Tokyo Metropolitan Health and Hospitals Corporation, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Takashi NakagawaDepartment of Respiratory Medicine, Toshima Hospital, Tokyo Metropolitan Health and Hospitals Corporation, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Shun YokotaDepartment of Internal Medicine, Division of Respiratory Medicine, Nihon University School of Medicine, 30-1, Oyaguchikamicho, Itabashi-Ku, Tokyo, 173-8601, Japan.
Eichi TakahashiDepartment of Respiratory Medicine, Toshima Hospital, Tokyo Metropolitan Health and Hospitals Corporation, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Yuji YamakawaDepartment of Respiratory Medicine, Toshima Hospital, Tokyo Metropolitan Health and Hospitals Corporation, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Akifumi HirataDepartment of Internal Medicine, Division of Respiratory Medicine, Nihon University School of Medicine, 30-1, Oyaguchikamicho, Itabashi-Ku, Tokyo, 173-8601, Japan.
Koumei IgeiDepartment of Respiratory Medicine, Toshima Hospital, Tokyo Metropolitan Health and Hospitals Corporation, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Naoki OkamotoDepartment of Respiratory Medicine, Toshima Hospital, Tokyo Metropolitan Health and Hospitals Corporation, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Masahiko IchiokaDepartment of Respiratory Medicine, Toshima Hospital, Tokyo Metropolitan Health and Hospitals Corporation, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Nihon University · JPToshima Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 75-year-old woman who had been taking methotrexate presented to our hospital for fever and dry cough. Chest computed tomography showed ground-glass opacity in the upper lobe of the right lung and foreign bodies in the lower lobe of the right bronchus. During bronchoscopy, foreign bodies were removed from the airway. We found increased levels of lymphocytes and a high CD4/CD8 ratio in the bronchoalveolar lavage fluid. Transbronchial lung biopsy revealed lymphocytic infiltration. Methotrexate was discontinued, and the imaging findings improved. Methotrexate-induced lung injury does occur unilaterally. Foreign bodies in the airway might also trigger unilateral methotrexate-induced lung injury.

Indexed as

Airway foreign bodyBALF, bronchoalveolar lavage fluidC7HRP, cytomegalovirus pp65 antigenCT, computed tomographyDLST, drug lymphocyte stimulation testDrug-induced lung injuryILI, induced lung injuryInterstitial lung diseaseKL-6, Krebs von den Lungen 6MethotrexateMTX, methotrexatePneumoniaT-SPOT.TB, tuberculosis-specific interferon-γUnilateral

Identifiers

PMID35036304
PMCPMC8749056
OpenAlexW4205376693

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.