Evidence map›Paper›PMID 35036069›Full record

ArticleMolecular therapy. Nucleic acids2022

Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells.

Tomasz Adamus, Chia-Yang Hung, Chunsong Yu, Elaine Kang, Mohamed Hammad, Linda Flores, Sergey Nechaev, Qifang Zhang, Joanna Marie Gonzaga, Kokilah Muthaiyah and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 78 citations in OpenAlex.

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  16. A Review of Silica-Based Nanoplatforms for Anticancer Cargo Delivery.International journal of molecular sciences · 2025
    Review
  17. Clinical applications of oligonucleotides for cancer therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Tomasz AdamusDepartment of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Chia-Yang HungDepartment of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Chunsong YuDepartment of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Elaine KangDepartment of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Mohamed HammadDepartment of Developmental and Stem Cell Biology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Linda FloresDepartment of Developmental and Stem Cell Biology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Sergey NechaevDepartment of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Qifang ZhangDepartment of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Joanna Marie GonzagaDepartment of Developmental and Stem Cell Biology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Kokilah MuthaiyahDNA/RNA Synthesis Laboratory, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Piotr SwiderskiDNA/RNA Synthesis Laboratory, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Karen S AboodyDepartment of Developmental and Stem Cell Biology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Marcin KortylewskiDepartment of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
City of Hope · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Cell-Selective CpG-STAT3 Inhibitors for Radioimmunotherapy of Malignant GliomaR01CA215183 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI KORTYLEWSKI, MARCIN · 2018 to 2022
$2.3M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA215183
6 · The paper itself

Abstract

Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and tolerogenic signal transducer and activator of transcription 3 (STAT3) protein into glioma microenvironment. To enable spontaneous, scavenger receptor-mediated endocytosis by NSCs, we used previously described CpG-STAT3ASO conjugates. Following uptake and endosomal escape, CpG-STAT3ASO colocalized with CD63

Indexed as

antisense oligonucleotidescancer immunotherapyCpGexosomesextracellular vesiclesgliomaneural stem cellsSTAT3TLR9

Identifiers

PMID35036069
PMCPMC8752899
OpenAlexW4200148117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.