Evidence map›Paper›PMID 35036035›Full record

ArticleChina CDC weekly2021

Molecular Epidemiological Characteristics of Gastroenteritis Outbreaks Caused by Norovirus GII.4 Sydney [P31] Strains - China, October 2016-December 2020.

Xi Zhu, Yaqing He, Xingyan Wei, Xiangyu Kong, Qing Zhang, Jingxin Li, Miao Jin, Zhaojun Duan

Open access · diamondAbstract read
In one paragraph

Article in China CDC weekly, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  5. Clinical and Genotypic Features of Norovirus Enteritis in Children Complicated by Convulsions: A Retrospective Study in Kunming, China.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  6. [Development of a Reverse Transcription Loop-Mediated Isothermal Amplification Assay for the Detection of Genogroup Ⅱ Norovirus].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
  7. Epidemiology of Norovirus Outbreaks in Kindergartens, Primary Schools, and Junior High Schools in Xi'an, China, From October 2020 to February 2023.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xi ZhuKey Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Yaqing HeShenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China.
Xingyan WeiKey Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Xiangyu KongKey Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Qing ZhangKey Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Jingxin LiKey Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Miao JinKey Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Zhaojun DuanKey Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
Shenzhen Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman noroviruses are the leading cause of acute viral gastroenteritis (AGE) worldwide in all age groups. GII.4 strains have been the predominant genotype circulating globally over the last 2 decades and since 2012. GII.4 Sydney viruses have emerged and caused the majority of AGE outbreaks worldwide.

methodsData from norovirus outbreaks from the laboratory-based surveillance of norovirus outbreaks in China (CaliciNet China) between October 2016-December 2020 were analyzed.

resultsDuring October 2016-December 2020, 1,954 norovirus outbreaks were reported, and positive fecal samples from 1,352 (69.19%) outbreaks were genotyped. GII.4 Sydney [P31] viruses accounted for 2.1% (October 2016-August 2017), 5.5% (September 2017-August 2018), 3.3% (September 2018-August 2018), 26.6% (September 2019-August 2020), and and 1.1% (September 2020-December 2020) of GII outbreaks, respectively. Compared to reference strains of GII.4 Sydney [P31] from 2012 to 2013, 7 amino acid mutations in epitopes[A (297, 372 and 373), B (333), E (414), and H (309 and 310)] and 1 in human histo-blood group antigens binding site at site II 372 were found by analyzing 9 GII.4 Sydney [P31] complete genomic sequences.

conclusionsThis report identified the genomic variation of GII.4 Sydney [P31] from CaliciNet China. Continued surveillance with prompt genotyping and genetic analysis is necessary to monitor the emergence of novel GII.4 variants.

Indexed as

GII.4 Sydney[P31]NorovirusOutbreaks

Identifiers

PMID35036035
PMCPMC8742140
OpenAlexW4205912051

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.