Evidence map›Paper›PMID 35036025›Full record

ReviewImmune network2021

SARS-CoV-2 Omicron Mutation Is Faster than the Chase: Multiple Mutations on Spike/ACE2 Interaction Residues.

Sinae Kim, Tam T Nguyen, Afeisha S Taitt, Hyunjhung Jhun, Ho-Young Park, Sung-Han Kim, Yong-Gil Kim, Eun Young Song, Youngmin Lee, Hokee Yum and 7 more

Abstract readReview
In one paragraph

Review in Immune network, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Structural proteins of human coronaviruses: what makes them different?Frontiers in cellular and infection microbiology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. COVID-19: Some unresolved issues.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sinae KimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-7767-5845
Tam T NguyenLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-0282-7760
Afeisha S TaittLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0003-4504-1001
Hyunjhung JhunTechnical Assistance Center, Korea Food Research Institute, Wanju 55365, Korea.ORCID https://orcid.org/0000-0002-3694-9715
Ho-Young ParkResearch Group of Functional Food Materials, Korea Food Research Institute, Wanju 55365, Korea.ORCID https://orcid.org/0000-0002-3694-9715
Sung-Han KimDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0002-6596-8253
Yong-Gil KimDivision of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0002-8029-7355
Eun Young SongDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University, Collage of Medicine, Seoul 03080, Korea.ORCID https://orcid.org/0000-0003-1286-9611
Youngmin LeeDepartment of Medicine, Pusan Paik Hospital, Inje University College of Medicine, Busan 47392, Korea.
Hokee YumPulmonary Science and Critical Care Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul 04551, Korea.
Kyeong-Cheol ShinCenter for Respiratory Disease, College of Medicine, Yeungnam University, Daegu 42415, Korea.ORCID https://orcid.org/0000-0003-1972-1847
Yang Kyu ChoiCollege of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-4969-5443
Chang-Seon SongCollege of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-4158-6402
Su Cheong YeomGraduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea.ORCID https://orcid.org/0000-0002-9491-5740
Byoungguk KimDivision of Vaccine Clinical Research Center for Vaccine Research, National Institute of Infectious Diseases, Cheongju 28160, Korea.
Mihai NeteaDepartment of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen 6500HB, Netherlands.ORCID https://orcid.org/0000-0003-2421-6052
Soohyun KimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-0322-7935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (B.1.1.529) Omicron variant originated from South Africa in the middle of November 2021. SARS-CoV-2 is also called coronavirus disease 2019 (COVID-19) since SARS-CoV-2 is the causative agent of COVID-19. Several studies already suggested that the SARS-CoV-2 Omicron variant would be the fastest transmissible variant compared to the previous 10 SARS-CoV-2 variants of concern, interest, and alert. Few clinical studies reported the high transmissibility of the Omicron variant but there is insufficient time to perform actual experiments to prove it, since the spread is so fast. We analyzed the SARS-CoV-2 Omicron variant, which revealed a very high rate of mutation at amino acid residues that interact with angiostatin-converting enzyme 2. The mutation rate of COVID-19 is faster than what we prepared vaccine program, antibody therapy, lockdown, and quarantine against COVID-19 so far. Thus, it is necessary to find better strategies to overcome the current crisis of COVID-19 pandemic.

Indexed as

COVID-19 OmicronMutationReceptor binding motif (RBM)SARS-CoV-2Spike (S) gene

Identifiers

PMID35036025
PMCPMC8733186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.