ArticleClinical kidney journal2022
Correlations, agreement and utility of frailty instruments in prevalent haemodialysis patients: baseline cohort data from the FITNESS study.
Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis.BMC nephrology · 2023Pooled it
- Ultrasound quadriceps muscle thickness is variably associated with frailty in haemodialysis recipients.BMC nephrology · 2023Trial
- Exploring the Impact of Anesthesia on Postoperative Frailty Trajectories in Older Adults.World journal of surgery · 2026Article
- Translation, Cross-Cultural Adaptation and Validation of the Serbian Version of the Clinical Frailty Scale in Patients Undergoing Major Uro-Oncological Surgery.Healthcare (Basel, Switzerland) · 2026Article
- Frailty assessment in kidney transplantation: insights from a European survey.Clinical kidney journal · 2026Article
- Comparison of diagnostic characteristics of four frailty screening tools in maintenance hemodialysis patients.International urology and nephrology · 2026Article
- Frailty in Focus: A Scoping Review of Frailty Instruments from the Kidney Disease Aging Research Collaborative.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis.Kidney medicine · 2025Article
- Current status and development trends in CKD with frailty research from 2000 to 2021: a bibliometric analysis.Renal failure · 2024Review
- Usefulness of the Clinical Frailty Scale in patients with end-stage kidney disease.Clinical kidney journal · 2024Article
- Frailty in hemodialysis patients: results of a screening program and multidisciplinary interventions.Clinical kidney journal · 2023Article
- Frailty and Clinical Outcomes in Patients Treated With Hemodialysis: A Prospective Cohort Study.Kidney medicine · 2023Article
- Comparison between FRAIL Scale and Clinical Frailty Scale in predicting hospitalization in hemodialysis patients.Journal of nephrology · 2023Observational
- Cognitive Impairment, Frailty, and Adverse Outcomes Among Prevalent Hemodialysis Recipients: Results From a Large Prospective Cohort Study in the United Kingdom.Kidney medicine · 2023Article
- A clinical frailty scale obtained from MDT discussion performs poorly in assessing frailty in haemodialysis recipients.BMC nephrology · 2023Article
- Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization.Clinical kidney journal · 2023Article
- Somatic Symptoms of Depression Lose Association with Mortality upon Adjustment for Frailty: Analysis from the Fitness Haemodialysis Cohort.International journal of nephrology · 2023Article
- Gender Disparity in Expression of Sarcopenia in Haemodialysis Recipients: Analysis from the FITNESS Cohort.International journal of nephrology · 2023Article
- Healthy aging and chronic kidney disease.Kidney research and clinical practice · 2022Article
- Evaluation of the impact of an intradialytic exercise programme on sarcopaenia in very elderly haemodialysis patients.Clinical kidney journal · 2022Article
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8 authors.
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Abstract
backgroundFrailty is associated with poor outcomes for haemodialysis patients, but its prevalence is uncertain due to heterogeneous definitions. The aim of this study was to compare and contrast prevalence and features of commonly used frailty instruments in a British haemodialysis cohort.
methodsThe FITNESS (Frailty Intervention Trial iN End-Stage patientS on haemodialysis) study recruited adults aged ≥18 years after informed consent, with ≥3 months haemodialysis exposure and no hospital admission within 4 weeks unless for dialysis access. Study participants were clinically phenotyped with frailty instruments including the Frailty Index (FI), Frailty Phenotype (FP), Edmonton Frailty Scale (EFS) and Clinical Frailty Scale (CFS), alongside comprehensive baseline data collection of biochemical, clinical and social characteristics.
resultsBetween 12 January 2018 and 18 April 2019, 485 haemodialysis patients were recruited. Baseline demographics were median age 63 years, male sex 58.6% and non-White ethnicity 42.1%. Prevalence of frailty was high; 41.9% of participants were frail by FP, 63.3% by FI, 50.2% by EFS and 53.8% by CFS. Female gender was associated with increased frailty, with no independent association observed with age or ethnicity. While correlation between frailty instruments was strong, intraclass correlation coefficient for frailty agreement was 0.628 (95% confidence interval 0.585-0.669) and only weak agreement between instrument pairs.
conclusionFrailty is highly prevalent among haemodialysis patients regardless of criteria used. However, our data suggest caution when interpreting heterogenous definitions of frailty for haemodialysis patients as they are not interchangeable. Consensus agreement on the optimal frailty definition for haemodialysis patients must balance ease of use with predictive ability for adverse outcomes before determining clinical application.
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