ArticleClinical kidney journal2022
Frailty among chronic kidney disease patients on the kidney transplant waiting list: the sex-frailty paradox.
Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Frailty and incident cognitive impairment in patients with CKD: sex-frailty paradox in the Chronic Renal Insufficiency Cohort (CRIC).GeroScience · 2026Article
- Frailty assessment in kidney transplantation: insights from a European survey.Clinical kidney journal · 2026Article
- Baseline cardio-kidney-metabolic syndrome, its transition, and frailty: insights from the China Health and Retirement Longitudinal Study (CHARLS).European journal of medical research · 2026Article
- Association between muscle strength and echogenicity using greyscale ultrasound software: a diagnostic accuracy study in kidney transplant candidates.European journal of physical and rehabilitation medicine · 2025Article
- Infection Risk in Older Kidney Transplant Recipients: An Analysis in the Era of Expanded Age Limits.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Frailty Is Associated with Malnutrition-Inflammation Syndrome in Older CKD Patients.Nutrients · 2024Article
- Interaction of general obesity and abdominal obesity with frailty in patients with chronic kidney disease: a nationally representative analysis.Clinical kidney journal · 2024Article
- Patient and Caregiver Perspectives on Gender Disparity in Chronic Kidney Disease: Questionnaire Survey, Based on an Interview Study.American journal of nephrology · 2024Article
- Sex-specific time trends of long-term graft survival after kidney transplantation - a registry-based study.Renal failure · 2023Article
- Sex and gender disparity in kidney transplantation: Historical and future perspectives.Clinical transplantation · 2022Review
- Frailty and solid-organ transplant candidates: a scoping review.BMC geriatrics · 2022Article
- Increased mortality after kidney transplantation in mildly frail recipients.Clinical kidney journal · 2022Article
- Frailty in kidney transplantation: a review on its evaluation, variation and long-term impact.Clinical kidney journal · 2022Review
- Prevalence of frailty and cognitive impairment in older transplant candidates - a preview to the Kidney Transplantation in Older People (KTOP): impact of frailty on outcomes study.BMC nephrology · 2022Observational
- Frailty in the context of kidney transplantation.Jornal brasileiro de nefrologiaReview
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is defined as decreased physiologic reserve and resistance to stressors that predisposes patients towards poor health results. Its prevalence in chronic kidney disease (CKD) patients who are kidney transplant (KT) candidates is high. Frailty is associated with a higher rate of complications and mortality after transplant. It is unknown whether frailty phenotype differs depending on sex in this population.
methodsThis was a prospective longitudinal study of 455 KT candidates evaluated for frailty by physical frailty phenotype at the time of inclusion on the KT waiting list. Pre-frailty was defined as the presence of two criteria and frailty as three or more criteria. Univariate and multivariate analyses searched for associations of frailty status, frailty components and gender differences.
resultsThirty percent of the total cohort resulted to be pre-frail (20%) or frail (10.3%), but disparities were observed between sexes, with 22.5% of men and 47.2% of women falling into one of these categories. Among frailty criteria, women presented with a higher percentage of exhaustion (39.6% versus 17%) and slowness (22.2% versus 9.6%) compared with men. Comorbidity burden was higher among frail men, whereas social factors were poorer between frail women. Disability was common among those patients who were frail, both men and women.
conclusionsFrailty is twice as frequent in advanced CKD women as men. Frailty criteria distribution and phenotype seem to differ among sexes, which might have implications in terms of specific and individualized interventions to improve their status before transplantation.
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