Evidence map›Paper›PMID 35035826›Full record

ArticleJournal of healthcare engineering2022

Regulatory Role of Zinc in Allergic Rhinitis through the IL-33/ST2 Pathway.

Wulin Wen, Fengxia Yang, Xueliang Shen, Ningyu Feng, Huiyu Ha, Ruixia Ma

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

  • Retraction · 2023-08-09Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Informed/Patient Consent - None/Withdrawn · Investigation by Journal/Publisher · Investigation by Third Party · Lack of IRB/IACUC Approval and/or Compliance · Paper Mill · Computer-Aided Content or Computer-Generated Content · Unreliable Results and/or Conclusions ·
  • Retracted
5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wulin WenDepartment of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital of Ningxia Medical University, The First People's Hospital of Yinchuan, Ningxia 753000, China.
Fengxia YangDepartment of Otolaryngology Head and Neck Surgery, The Third People's Hospital of Yinchuan, Ningxia 753000, China.
Xueliang ShenDepartment of Otolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Ningxia 753000, China.
Ningyu FengDepartment of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital of Ningxia Medical University, The First People's Hospital of Yinchuan, Ningxia 753000, China.
Huiyu HaDepartment of Otolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Ningxia 753000, China.
Ruixia MaDepartment of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital of Ningxia Medical University, The First People's Hospital of Yinchuan, Ningxia 753000, China.ORCID 0000-0002-8586-4734
Ningxia Medical University · CNNingxia Hui Autonomous Region Peoples Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to investigate the expression of serum zinc and cytokines interleukin- (IL-) 13 and IL-33 in patients with allergic rhinitis (AR) and observe the effects of zinc on cytokines and pathway proteins in P815 mast cells stimulated by Artemisia annua allergen (Art.) in the IL-33/suppression of the tumorigenicity 2 (ST2) pathway. We also aimed to explore the possible regulatory role of zinc in AR and provide new ideas to determine the etiology and treatment of AR.

methodsAR patients treated from March to September in 2018 were selected as the research participants, and 50 healthy people in the same period were selected as the control group. Serum samples of all patients were collected, and those of AR patients were tested for the presence of allergens. The expression of IL-13 and IL-33 was detected by performing an enzyme-linked immunosorbent assay, while the serum zinc level was detected by conducting an inductively coupled plasma mass spectrometry. The cell counting kit (CCK-8) was used to detect the proliferation of P815 mast cells, and western blot was used to detect the expression of ST2, p38, and p65 proteins.

resultsA total of 92 AR patients were included in the study; of them, 52 had mild AR, while 40 had moderate AR. The primary allergen found in AR patients was Artemisia, and the positivity rate was 53.26%. The serum zinc ion level of AR patients decreased, and the expression of IL-13 and IL-33 increased. After Art. was used to treat P815 mast cells, the expression of IL-33 in the cell supernatant increased in a concentration-dependent manner, the expression of receptor ST2 increased, and the expression of downstream p38 and p65 proteins increased. However, after treatment with ZnSO

conclusionThe serum zinc level of AR patients decreased. In the IL-33/ST2 pathway, ZnSO

Indexed as

Interleukin-33Rhinitis, AllergicAllergensCytokinesHumansInterleukin-13Interleukin-1 Receptor-Like 1 ProteinZincAllergensCytokinesInterleukin-13Interleukin-1 Receptor-Like 1 ProteinInterleukin-33Zinc

Identifiers

PMID35035826
PMCPMC8759868
OpenAlexW4205850236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.