Evidence map›Paper›PMID 35035790›Full record

ArticleComputational and structural biotechnology journal2022

Homologous cardiac calcium pump regulators phospholamban and sarcolipin adopt distinct oligomeric states in the membrane.

Andy Y Liu, Rodrigo Aguayo-Ortiz, Guadalupe Guerrero-Serna, Nulang Wang, Muriel G Blin, Daniel R Goldstein, L Michel Espinoza-Fonseca

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Andy Y LiuCenter for Arrhythmia Research, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Rodrigo Aguayo-OrtizDepartamento de Farmacia, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Guadalupe Guerrero-SernaCenter for Arrhythmia Research, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Nulang WangCenter for Arrhythmia Research, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Muriel G BlinDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel R GoldsteinDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
L Michel Espinoza-FonsecaCenter for Arrhythmia Research, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · USUniversidad Nacional Autónoma de México · MX

Funding

Mechanisms to augment primary immunity in agingR01AG028082 · NIA · YALE UNIVERSITY · PI DENG, JANE C · 2007 to 2023
$6.9M
Novel mechanisms of age-enhanced vasculopathy after heart transplantationR01AI138347 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDSTEIN, DANIEL ROBERT · 2018 to 2022
$2.7M
Role of mitophagy in age-related respiratory and vascular diseasesR35HL155169 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDSTEIN, DANIEL ROBERT · 2021 to 2023
$1.8M
Molecular mechanisms and regulation of the calcium pump in the heartR01GM120142 · NIGMS · UNIVERSITY OF MINNESOTA · PI ESPINOZA-FONSECA, LENNANE MICHEL · 2016 to 2020
$1.7M
NHLBI NIH HHS R35 HL155169NIAID NIH HHS R01 AI138347NIA NIH HHS R01 AG028082NIGMS NIH HHS R01 GM120142
6 · The paper itself

Abstract

Phospholamban (PLN) and Sarcolipin (SLN) are homologous membrane proteins that belong to the family of proteins that regulate the activity of the cardiac calcium pump (sarcoplasmic reticulum Ca

Indexed as

Calcium pumpCardiac calcium regulationiPSC, induced pluripotent stem cellsMD, molecular dynamicsMembrane proteinsOligomerizationPhospholambanPLN, phospholambanPOPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholineSarcolipinSERCA, sarcoplasmic reticulum Ca2+-ATPase;SLN, sarcolipin

Identifiers

PMID35035790
PMCPMC8748397
OpenAlexW4200475748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.