ArticleAmerican journal of translational research2021
Study on individualized analgesia guided by
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 0 citations in OpenAlex.
- Impact of CYP Enzyme Polymorphisms on Opioid Response in Anesthesia and Pain Medicine.Pain research & management · 2026Review
- Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose.PharmacogenomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the significance of CYP3A4 and CYP3A5 genetic polymorphisms in achieving personalized fentanyl application in patients undergoing thoracoscopic operation.
methodsThis was a retrospective study. One hundred patients with lung cancer received thoracoscopic surgery operation under the conditions of general anesthesia. According to the results of individualized analgesia guided by CYP3A4/5 polymorphisms, the patients were assigned into three groups: group I (the wild-type homozygote, the induced dosage of fentanyl: 6 µg/kg, the background infusion rate of patient-controlled intravenous analgesia (PCIA): 2 mL/h), group II (the heterozygote, the induced dosage of fentanyl: 5 µg/kg, the background infusion rate of PCIA: 1.5 mL/h), and group III (the mutant homozygote, the induced dosage of fentanyl: 4 µg/kg, the background infusion rate of PCIA: 1 mL/h). The locking-time was 15 min. A visual analog scale (VAS) score less than 3 points suggested effective analgesia. The times of operation and recovery were examined. Surgical plethysmography index (SPI), blood glucose levels, VAS and bruggemann comfort scale (BCS) scores at different time points were recorded, respectively. Total consumption of fentanyl, the effective time of PCIA compression, and the incidence of adverse drug reactions were also recorded.
resultsThere were no statistical differences in SPI, blood glucose level, VAS, BCS scores and incidence of adverse reactions among the three groups. In term of intraoperative, postoperative fentanyl doses and the amount of effective PCA, significant differences were found among the groups (P < 0.05).
conclusionAccording to the genotype of
Indexed as
Identifiers
35035767PMC8748095W4206887793What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.