Evidence map›Paper›PMID 35035750›Full record

ArticleAmerican journal of translational research2021

miR-125a-5p-targeted regulation of TRA2β expression inhibits proliferation and metastasis of hepatocellular carcinoma cells.

Junde Zhou, Linna Wang, Yunfu Cui, Lanhua Tang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Junde ZhouWard 3 of General Surgery, The Second Affiliated Hospital of Harbin Medical University Harbin 150086, Heilongjiang, China.
Linna WangThe Sixth Department of Oncology, General Hospital of Heilongjiang General Bureau of Land Reclamation Harbin 150088, Heilongjiang, China.
Yunfu CuiWard 1 of General Surgery, The Second Affiliated Hospital of Harbin Medical University Harbin 150086, Heilongjiang, China.
Lanhua TangDepartment of Oncology, Xiangya Hospital, Central South University Changsha 410008, Hunan, China.
Harbin Medical University · CNCentral South University · CNHeilongjiang Academy of Land Reclamation Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the regulation of miR-125a-5p in hepatocellular carcinoma (HCC) and its mechanisms.

methodsBy transfecting a miR-125a-5p sequence and an interfering sequence of miR-125a-5p-s into human HCC cell lines HCC-LM3 and HepG2, miR-125a-5p-related levels were assesed by Western blot. The abilities of cell proliferation and migration were assessed by cell culture and Transwell assay, respectively.

resultsHepG2 cells showed increased miR-125a-5p levels compared with HCC-LM3 cells (

conclusionmiR-125a-5p inhibits the invasive capacity of HCC cells through targeting the TRA2β pathway.

Indexed as

hepatocellular carcinomainvasionmicroRNA-125aTRA2β

Identifiers

PMID35035750
PMCPMC8748114
OpenAlexW4206866517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.