ArticleAmerican journal of translational research2021
Laparoscopic radical resection combined with neoadjuvant chemotherapy in treatment of colorectal cancer: clinical efficacy and postoperative complications.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Music therapy combined with anesthesia recovery care boosts anesthesia recovery in colorectal cancer patients undergoing laparoscopic radical resection.World journal of gastrointestinal surgery · 2025Article
- Predictive value of physiological capacity and surgical stress scores for perioperative complications in radical resection for colorectal cancer: a propensity-matched analysis.American journal of translational research · 2025Article
- Prediction model construction for the occurrence of LARS after neoadjuvant therapy combined with laparoscopic total mesorectal excision in male patients with mid-low rectal cancer.Frontiers in oncology · 2024Article
- Artificial intelligent patient-controlled intravenous analgesia improves the outcomes of older patients with laparoscopic radical resection for colorectal cancer.European geriatric medicine · 2023Article
- Efficacy of Laparoscopic Radical Resection Combined with Neoadjuvant Chemotherapy and Its Impact on Long-Term Prognosis of Patients with Colorectal Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the clinical efficacy of laparoscopic radical resection combined with neoadjuvant chemotherapy (NACT) in the treatment of colorectal cancer and its influence on postoperative complications.
methodsThe clinical data of 90 patients with colorectal cancer admitted to our hospital from June 2019 to June 2021 were retrospectively analyzed. According to different treatment methods, patients were divided into a control group (laparoscopic radical resection) and a study group (combined NACT before radical resection), with 45 cases in each group. The efficacy and complications were compared between the two groups after treatment.
resultsPostoperatively, the early oral feeding, anal exhaust time, and hospitalization time of the patients in the study group were significantly shorter than those in the control group (P<0.05). The study group had significantly lower cancer metastasis rate, recurrence rate, infection rate, and smaller tumor diameters than the control group (P<0.05). The levels of tumor markers (CEA, CA242, CA199, and CA724) were reduced significantly in both groups after treatment, with lower results observed in the study group (P<0.05). The average survival time of patients in the study group was significantly longer than that of the control group (16.04±3.64 vs 11.88±2.53 months; t=6.295, P<0.001). The two groups showed no significant differences in the incidence of complications (P>0.05).
conclusionLaparoscopic radical resection of colorectal cancer combined with NACT is a preferred technique for the treatment of colorectal cancer. It effectively facilitates the postoperative recovery, reduces the levels of tumor markers, boosts the short-term curative effect, and prolongs the average survival time, without obvious complications.
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Identifiers
35035739PMC8748148W4206873694What OpenQuestion holds
Registered trials
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