ArticleAmerican journal of translational research2021
miR-34a overexpression protects against hippocampal neuron damage caused by ketamine-induced anesthesia in immature rats through the Notch-1/NF-κB signaling pathway.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Epigenetic mechanisms of rapid-acting antidepressants.Translational psychiatry · 2024Review
- LncGBP9 knockdown alleviates myocardial inflammation and apoptosis in mice with acute viral myocarditis via suppressing NF-κB signaling pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the protective effect of miR-34a overexpression on hippocampal neuron damage caused by ketamine-induced anesthesia in immature rats and the underlying mechanism.
methodsA total of 48 male SD rats were divided into control group (CG, n=12), ketamine group (KG, n=12), negative control group (NCG, n=12), and intervention group (IG, n=12) by using the random number table method. Neurological function, cognitive function, pathological changes of brain tissues, inflammatory cytokines, as well as mRNA expression levels of Notch-1, NICD, RBP-JK, and Hes-1 in brain tissues were detected in the four groups.
resultsThe scores of auricular, paw withdrawal, corneal reflex, and escape reflexes of IG were higher than those of KG and NCG (
conclusionsmiR-34a overexpression exhibited a potent protective effect on hippocampal neuron damage caused by ketamine-induced anesthesia in immature rats.
Indexed as
Identifiers
35035687PMC8748079W4206855704What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.