Evidence map›Paper›PMID 35035675›Full record

ReviewAmerican journal of translational research2021

Roles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases.

Qinghong Chen, Junlin Fang, Hui Shen, Liping Chen, Mengying Shi, Xianbao Huang, Zhiwei Miao, Yating Gong

Open access · greenAbstract readReview
In one paragraph

Review in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Dystonic Tremor as Main Clinical Manifestation of SCA21.Movement disorders clinical practice · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Qinghong ChenAffiliated Hospital of Jiangxi University of Traditional Chinese Medicine Nanchang 330006, Jiangxi, China.
Junlin FangDepartment of Acupuncture and Moxibustion, Banan Hospital of Traditional Chinese Medicine Chongqing 401320, China.
Hui ShenZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215600, Jiangsu, China.
Liping ChenZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215600, Jiangsu, China.
Mengying ShiZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215600, Jiangsu, China.
Xianbao HuangAffiliated Hospital of Jiangxi University of Traditional Chinese Medicine Nanchang 330006, Jiangxi, China.
Zhiwei MiaoZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215600, Jiangsu, China.
Yating GongZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215600, Jiangsu, China.
Nanjing University of Chinese Medicine · CNAffiliated Hospital of Jiangxi University of Traditional Chinese Medicine · CNFirst People's Hospital of Chongqing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transmembrane protein family members (TMEMs) span the entire lipid bilayer and act as channels that allow the transport of specific substances through biofilms. The functions of most TMEMs are unexplored. Numerous studies have shown that TMEMs are involved in the pathophysiological processes of various nervous system diseases, but the specific mechanisms of TMEMs in the pathogenesis of diseases remain unclear. In this review, we discuss the expression, physiological functions, and molecular mechanisms of TMEMs in brain tumors, psychiatric disorders, abnormal motor activity, cobblestone lissencephaly, neuropathic pain, traumatic brain injury, and other disorders of the nervous system. Additionally, we propose that TMEMs may be used as prognostic markers and potential therapeutic targets in patients with various neurological diseases.

Indexed as

abnormal actionnervous systempsychiatric disorderTMEMstumor

Identifiers

PMID35035675
PMCPMC8748174
OpenAlexW4206881715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.