Evidence map›Paper›PMID 35035655›Full record

ArticleOxidative medicine and cellular longevity2022

Novel lncRNA AL033381.2 Promotes Hepatocellular Carcinoma Progression by Upregulating PRKRA Expression.

Feiran Wang, Lirong Zhu, Qiang Xue, Chong Tang, Weidong Tang, Nannan Zhang, Chen Dai, Zhong Chen

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. DNA repair in tumor radioresistance: insights from fruit flies genetics.Cellular oncology (Dordrecht, Netherlands) · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Feiran WangMedical College of Nantong University, Nantong, Jiangsu 226000, China.ORCID https://orcid.org/0000-0003-3186-0663
Lirong ZhuDepartment of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, China.ORCID https://orcid.org/0000-0002-5563-8568
Qiang XueDepartment of Radiotherapy, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, China.ORCID https://orcid.org/0000-0002-0493-5685
Chong TangDepartment of General Surgery, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu 226000, China.ORCID https://orcid.org/0000-0002-1544-980X
Weidong TangDepartment of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, China.ORCID https://orcid.org/0000-0002-7217-8380
Nannan ZhangMedical College of Nantong University, Nantong, Jiangsu 226000, China.ORCID https://orcid.org/0000-0002-7948-2369
Chen DaiInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, Hubei 430030, China.ORCID https://orcid.org/0000-0002-3607-1682
Zhong ChenDepartment of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, China.ORCID https://orcid.org/0000-0002-4891-259X
Nantong University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a common malignant tumor that is characterized by aggressiveness and poor prognosis. Accumulating evidence indicates that oxidative stress plays a crucial role in carcinogenesis, whereas the potential mechanism between oxidative stress and carcinogenic effects remains elusive. In recent years, long noncoding RNAs (lncRNAs) in cancers have attracted extensive attention and have been shown to be involved in oxidative stress response and carcinogenesis. Nevertheless, the roles of lncRNA AL033381.2 in regulating the development and progression of HCC still remain unclear. The purpose of our study was to evaluate the potential effects and molecular mechanisms of AL033381.2 that may be involved in oxidative stress response in HCC. Using bioinformatics analyses based on the TCGA database, we screened and identified a novel lncRNA AL033381.2 in HCC, which may be involved in oxidative stress responses. qRT-PCR analysis revealed that AL033381.2 is upregulated in HCC tissues. Through

Indexed as

Carcinoma, HepatocellularCell ProliferationDisease ProgressionHumansLiver NeoplasmsPrognosisRNA-Binding ProteinsTransfectionUp-RegulationPRKRA protein, humanRNA-Binding Proteins

Identifiers

PMID35035655
PMCPMC8759831
OpenAlexW4206624676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.