Evidence map›Paper›PMID 35035506›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2022

(E)-9-Octadecenoic Acid Ethyl Ester Derived from Lotus Seedpod Ameliorates Inflammatory Responses by Regulating MAPKs and NF-

Chuanqi Xie, Shufen Wang, Mingyuan Cao, Wei Xiong, Lei Wu

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  3. In Vitro Investigation of the Cytotoxic and Antioxidant Activities ofAdvances in pharmacological and pharmaceutical sciences · 2025
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  4. Nephroprotective Potential of LyophilizedJournal of nutrition and metabolism · 2025
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  8. Anti-Inflammatory and Antioxidant Activities of Lipophilic Fraction fromInternational journal of molecular sciences · 2023
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  12. In Vitro and In Vivo Nephroprotective Effects ofPlants (Basel, Switzerland) · 2022
    Article
  13. Hepatoprotective Activity ofMolecules (Basel, Switzerland) · 2022
    Article
  14. Article
  15. The polysaccharide fromFood & nutrition research · 2022
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  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chuanqi XieInstitute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China.ORCID https://orcid.org/0000-0002-4647-1209
Shufen WangInstitute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China.
Mingyuan CaoInstitute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China.
Wei XiongInstitute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China.ORCID https://orcid.org/0000-0002-7744-2638
Lei WuInstitute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China.ORCID https://orcid.org/0000-0002-5338-4250
Jiangxi Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is generally considered a key risk factor in the progress of several chronic diseases, such as arthritis, gastritis, and hepatitis. Natural products with anti-inflammatory ability have played a great role in the process of overcoming these inflammatory diseases. In this study, we evaluated the anti-inflammatory activities of ten natural compounds derived from lotus seedpod and discovered (E)-9-octadecenoic acid ethyl ester (E9OAEE) inhibited the production of nitric oxide (NO) optimally in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Furthermore, we explored the effects of E9OAEE on inflammatory responses and the underlying mechanisms in LPS-induced RAW264.7 macrophages. The results indicated that E9OAEE significantly suppressed the production of NO, prostaglandin E2 (PGE2), and tumour necrosis factor-

Identifiers

PMID35035506
PMCPMC8754602
OpenAlexW4206049878

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.