Evidence map›Paper›PMID 35034653›Full record

Trial reportJournal of neuroengineering and rehabilitation2022

Peripheral magnetic theta burst stimulation to muscles can effectively reduce spasticity: a randomized controlled trial.

Nevine El Nahas, Fatma Fathalla Kenawy, Eman Hamid Abd Eldayem, Tamer M Roushdy, Shahinaz M Helmy, Ahmed Zaki Akl, Aya Ahmed Ashour, Tamer H Emara, Marwa Mohamed Moawad, Randa M Amin and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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  13. [The research progress on the improvement effect of repeated peripheral magnetic stimulation on upper limb and lower limb spasm after stroke].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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  19. Emerging theory of sensitization in post-stroke muscle spasticity.Frontiers in rehabilitation sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Nevine El NahasAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Fatma Fathalla KenawyAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt. fatma.fathalla@med.asu.edu.eg.ORCID 0000-0003-1444-4254
Eman Hamid Abd EldayemAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Tamer M RoushdyAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Shahinaz M HelmyAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Ahmed Zaki AklAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Aya Ahmed AshourAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Tamer H EmaraAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Marwa Mohamed MoawadNeurology Specialist, Ministry of Health, Cairo, Egypt.
Randa M AminAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Ahmed M ElboklAin Shams Neuromodulation Research Lab, Neurology Department, Faculty of Medicine, Ain Shams University, P. O. Box 1159, Cairo, Egypt.
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpasticity is a common complication of many neurological diseases and despite contributing much disability; the available therapeutic options are limited. Peripheral magnetic stimulation is one promising option. In this study, we investigated whether peripheral intermittent theta burst stimulation (piTBS) will reduce spasticity when applied directly on spastic muscles.

methodsIn this sham-controlled study, eight successive sessions of piTBS were applied directly to spastic muscles with supra threshold intensity. Assessment was done by modified Ashworth scale (mAS) and estimated Botulinum toxin dose (eBTD) at baseline and after the 8th session in both active and sham groups.

resultsA total of 120 spastic muscles of 36 patients were included in the analysis. Significant reduction of mAS and eBTD was found in the active compared to sham group (p < 0.001). The difference in mAS was also significant when tested in upper limb and lower limb subgroups. The degree of reduction in mAS was positively correlated with the baseline scores in the active group.

conclusionpiTBS could be a promising method to reduce spasticity and eBTD. It consumes less time than standard high frequency protocols without compromising treatment efficacy.

trial registrationClinical trial registry number: PACTR202009622405087. Retrospectively Registered 14th September, 2020.

Indexed as

Botulinum Toxins, Type AStrokeHumansMagnetic PhenomenaMusclesMuscle SpasticityTranscranial Magnetic StimulationTreatment OutcomeBotulinum Toxins, Type ABotulinum Toxin DosePeripheral Magnetic StimulationSpasticityTheta Burst Stimulation

Identifiers

PMID35034653
PMCPMC8762845
OpenAlexW4205435732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.