Evidence map›Paper›PMID 35034638›Full record

ArticleJournal of cardiothoracic surgery2022

Is postoperative cognitive decline after cardiac surgery associated with plasma beta amyloid 1-42 levels?

Zrinka Požgain, Grgur Dulić, Goran Kondža, Siniša Bogović, Ivan Šerić, Dejan Hil, Bojan Trogrlić, Ana Bednjanić, Marina Perković-Kovačević, Ines Šahinović

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zrinka PožgainDepartment of Abdominal Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia. zrinkapozgain@outlook.com.ORCID http://orcid.org/0000-0003-2690-3462
Grgur DulićDepartment of Cardiac Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Goran KondžaDepartment of Abdominal Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Siniša BogovićDepartment of Cardiac Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Ivan ŠerićDepartment of Abdominal Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Dejan HilDepartment of Abdominal Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Bojan TrogrlićDepartment of Abdominal Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Ana BednjanićDepartment of Abdominal Surgery, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Marina Perković-KovačevićDepartment of Psychiatry, University Hospital Centre Osijek, J. Huttlera 4, 31000, Osijek, Croatia.
Ines ŠahinovićDepartment of Clinical Laboratory Diagnostics, University Hospital Centre Osijek, J. J. Strossmayer University of Osijek, J. Huttlera 4, Osijek, Croatia.
Klinički bolnički centar Osijek · HRUniversity of Osijek · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative cognitive decline following cardiac surgery is one of the frequently reported complications affecting postoperative outcome, characterized by impairment of memory or concentration. The aetiology is considered multifactorial and the research conducted so far has presented contradictory results. The proposed mechanisms to explain the cognitive decline associated with cardiac surgery include the neurotoxic accumulation of β-amyloid (Aβ) proteins similar to Alzheimer's disease. The comparison of coronary artery bypass grafting procedures concerning postoperative cognitive decline and plasmatic Aβ1-42 concentrations has not yet been conducted.

methodsThe research was designed as a controlled clinical study of patients with coronary artery disease undergoing surgical myocardial revascularization with or without the use of a cardiopulmonary bypass machine. All patients completed a battery of neuropsychological tests and plasmatic Aβ1-42 concentrations were collected.

resultsThe neuropsychological test results postoperatively were significantly worse in the cardiopulmonary bypass group and the patients had larger shifts in the Aβ1-42 preoperative and postoperative values than the group in which off-pump coronary artery bypass was performed.

conclusionsThe conducted research confirmed the earlier suspected association of plasmatic Aβ1-42 concentration to postoperative cognitive decline and the results further showed that there were less changes and lower concentrations in the off-pump coronary artery bypass group, which correlated to less neurocognitive decline. There is a lot of clinical contribution acquired by this research, not only in everyday decision making and using amyloid proteins as biomarkers, but also in the development and application of non-pharmacological and pharmacological neuroprotective strategies.

Indexed as

Cognitive DysfunctionCoronary Artery Bypass, Off-PumpAmyloid beta-PeptidesCardiopulmonary BypassCoronary Artery BypassHumansPostoperative ComplicationsAmyloid beta-PeptidesAmyloid fibrilsCognitive dysfunctionCoronary artery bypass surgery

Identifiers

PMID35034638
PMCPMC8762893
OpenAlexW4206316426

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.