Evidence map›Paper›PMID 35034529›Full record

ArticlePalliative medicine2022

Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique.

Jamilla A Hussain, Ian R White, Miriam J Johnson, Anthony Byrne, Nancy J Preston, Andy Haines, Kathy Seddon, Tim J Peters

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Palliative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06567340 (StratCare Trial 2), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06567340 narecruitingnot on this mapstarted 2025, after this paper: background citation

StratCare Trial 2: Evaluating the Clinical and Cost-effectiveness of AI-driven Stratified Care for Depression

TypeinterventionalSponsorRotherham Doncaster and South Humber NHS Foundation TrustRan2025 to 2027Enrolled1,252ConditionsDepressionArmsStratCare
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Jamilla A HussainWolfson Palliative Care Research Centre, University of Hull, Hull, UK.ORCID 0000-0002-3644-6480
Ian R WhiteMRC Clinical Trials Unit, University College London, London, UK.
Miriam J JohnsonWolfson Palliative Care Research Centre, University of Hull, Hull, UK.
Anthony ByrneMarie Curie Palliative Care Research Centre, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-1413-1496
Nancy J PrestonInternational Observatory on End of Life Care, Lancaster University, Lancaster, UK.ORCID 0000-0003-2659-2342
Andy HainesDepartment of Public Health, Environments and Society and Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Kathy SeddonMarie Curie Research Voice, Wales Cancer Research Centre, Cardiff University, Cardiff, UK.
Tim J PetersPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Marie Curie · GBUniversity of Hull · GBLancaster University · GBLondon School of Hygiene & Tropical Medicine · GBMRC Clinical Trials Unit at UCL · GBUniversity of Bristol · GB

Funding

Department of Health DRF-2013-06-001Medical Research Council MC_UU_00004/07Medical Research Council MC_UU_00004/09
6 · The paper itself

Abstract

backgroundMissing data can introduce bias and reduce the power, precision and generalisability of study findings. Guidelines on how to address missing data are limited in scope and detail, and poorly implemented.

aimTo develop guidelines on how best to (i) reduce, (ii) handle and (iii) report missing data in palliative care clinical trials.

designModified nominal group technique. SETTING/

participantsPatient and public research partners, palliative care clinicians, trialists, methodologists and statisticians attended a 1-day workshop, following which a multi-stakeholder development group drafted the guidelines.

resultsSeven main recommendations for reducing missing data, nine for handling missing data and twelve for reporting missing data were developed. The top five recommendations were: (i) train all research staff on missing data, (ii) prepare for missing data at the trial design stage, (iii) address missing data in the statistical analysis plan, (iv) collect the reasons for missing data and (v) report descriptive statistics comparing the baseline characteristics of those with missing and observed data. Reducing missing data, preparing for missing data and understanding the reasons for missing data were greater priorities for stakeholders than how to deal with missing data once they had occurred.

conclusionComprehensive guidelines on how to address missing data were developed by stakeholders involved in palliative care trials. Implementation of the guidelines will require endorsement of research funders and research journals.

Indexed as

Hospice and Palliative Care NursingPalliative CareData CollectionHumansResearch Designguidelinelost to follow upMissing datapalliative carepalliative medicinerandomised controlled trials

Identifiers

PMID35034529
PMCPMC8796167
OpenAlexW4206715243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.