Evidence map›Paper›PMID 35034456›Full record

ArticleACS applied bio materials2022

Probing Light-Stimulated Activities in the Retina via Transparent Graphene Electrodes.

Xiaosi Zhang, Hannah Lee, Yuchen Zhang, Thayer S Walmsley, Deyu Li, Edward Levine, Ya-Qiong Xu

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaosi ZhangDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-9414-9970
Hannah LeeDepartment of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37235, United States.
Yuchen ZhangDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.
Thayer S WalmsleyDepartment of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, United States.
Deyu LiDepartment of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-8364-0924
Edward LevineDepartment of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37235, United States.
Ya-Qiong XuDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0003-1423-7458
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Mapping Brain Activity with High Spatiotemporal Resolution using Graphene ProbesR01EY027729 · NEI · VANDERBILT UNIVERSITY · PI LI, DEYU · 2017 to 2021
$2.0M
NEI NIH HHS R01 EY027729
6 · The paper itself

Abstract

Graphene has triggered tremendous research due to its superior properties. In particular, the intrinsic high light transmission illustrates the unique advantage in neural biosensing. Here, we combine perforated flexible graphene electrodes with microfluidic platforms to explore real-time extracellular electrical activities of retinal ganglion cells (RGCs). Under light stimulation, the transparent graphene electrodes have demonstrated the capability of recording the electrical activities of stimulated RGCs in direct contact. Different types of RGCs have shown three distinct light induced patterns, ON, OFF, and ON-OFF, which are primarily operated by cone photoreceptors. Moreover, the observed spiking waveforms can be divided into two groups: the biphasic waveform usually occurs at contacts with soma, while the triphasic waveform is likely related to the axon. Under high K

Indexed as

GraphiteElectric StimulationElectrodesRetinaRetinal Ganglion CellsGraphiteelectrical activitiesgrapheneK+ stimulationlight stimulationretinaspiking waveform sorting

Identifiers

PMID35034456
PMCPMC10505038
OpenAlexW4206730915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.