Evidence map›Paper›PMID 35034430›Full record

ArticleChemMedChem2022

Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y

Anne Zimmermann, Oanh Vu, Antje Brüser, Gregory Sliwoski, Lawrence J Marnett, Jens Meiler, Torsten Schöneberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anne ZimmermannRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany.
Oanh VuDepartment of Chemistry, Center for Structural Biology, Vanderbilt University, TN 37232-8725, Nashville, USA.
Antje BrüserRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany.
Gregory SliwoskiDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, TN 37232-8725, Nashville, USA.
Lawrence J MarnettVanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, TN 37232-0146, Nashville, USA.
Jens MeilerDepartment of Chemistry, Center for Structural Biology, Vanderbilt University, TN 37232-8725, Nashville, USA.
Torsten SchönebergRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany.ORCID 0000-0001-5313-0237

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclooxygenase-2 catalyzes the biosynthesis of prostaglandins from arachidonic acid and the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol. PG-Gs are mediators of several biological actions such as macrophage activation, hyperalgesia, synaptic plasticity, and intraocular pressure. Recently, the human UDP receptor P2Y

Indexed as

DinoprostoneNucleotidesBinding SitesHumansUridine DiphosphateDinoprostoneNucleotidesprostaglandin E2 glyceryl esterUridine Diphosphatebinding siteG protein-coupled receptorsPGE2-Gsite-directed mutagenesisUDP

Identifiers

PMID35034430
PMCPMC9305961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.