Evidence map›Paper›PMID 35034286›Full record

ArticleMolecular biology reports2022

Probing the effects of sweet cherry (Prunus avium L.) extract on 2D and 3D human skin models.

Sophia Letsiou, Ioannis Ganopoulos, Aliki Kapazoglou, Aliki Xanthopoulou, Eirini Sarrou, Georgia Tanou, Athanassios Molassiotis

Abstract read
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In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sophia LetsiouInstitute of Plant Breeding and Genetic Resources, ELGO-DEMETER, 57001, Thessaloniki-Thermi, Greece. sletsiou@gmail.com.ORCID http://orcid.org/0000-0002-9155-0889
Ioannis GanopoulosInstitute of Plant Breeding and Genetic Resources, ELGO-DEMETER, 57001, Thessaloniki-Thermi, Greece.
Aliki KapazoglouInstitute of Olive Tree, Subtropical Crops and Viticulture (IOSV), Department of Vitis, ELGO-DEMETER, Lykovrysi, 14123, Athens, Greece.
Aliki XanthopoulouInstitute of Plant Breeding and Genetic Resources, ELGO-DEMETER, 57001, Thessaloniki-Thermi, Greece.
Eirini SarrouInstitute of Olive Tree, Subtropical Crops and Viticulture (IOSV), Department of Vitis, ELGO-DEMETER, Lykovrysi, 14123, Athens, Greece.
Georgia TanouInstitute of Soil and Water Resources, ELGO-DEMETER, 57001, Thessaloniki-Thermi, Greece.
Athanassios MolassiotisInstitute of Plant Breeding and Genetic Resources, ELGO-DEMETER, 57001, Thessaloniki-Thermi, Greece.
Federation of Greek Mariculture · GRAristotle University of Thessaloniki · GR

Funding

Hellenic Foundation for Research and Innovation 148
6 · The paper itself

Abstract

backgroundNatural products are not only positioned in the heart of traditional medicine but also in modern medicine as many current drugs are coming from natural sources. Apart from the field of medicine and therapeutics, natural products are broadly used in other industrial fields such as nutrition, skincare products and nanotechnology. METHODS AND

resultsThe aim of this study was to assess the effects of sweet cherry (Prunus avium L.) fruit extract from the Greek native cultivar 'Vasiliadi', on the human 2D and 3D in vitro models in order to investigate its potential impact on skin. We focused on 2D culture of primary normal human epidermal keratinocytes (NHEK) that were treated with sweet cherry fruit extract. In the first place, we targeted fruit extract potential cytotoxicity by determining ATP intracellular levels. Furthermore, we assessed its potential skin irritability by using 3D skin model. To better understand the bioactivity of sweet cherry fruit. extract, we used qPCR to study the expression of various genes that are implicated in the skin functions. Our experiments showed that sweet cherry fruit extract is non-toxic in 2D keratinocytes culture as well as non-irritant in 3D skin model. Our results revealed that the extract mediated important pathways for the optimum epidermis function such as cell proliferation, immune and inflammatory response.

conclusionThe sweet cherry fruit extracts possesses significant activity in epidermis function without any potential of cytotoxicity or skin irritability, which makes it a rather promising active agent for skincare.

Indexed as

Prunus aviumFruitHumansPlant ExtractsSkinPlant ExtractsIn vitroKeratinocytesNatural extractPrunus avium L.Sweet cherry fruit

Identifiers

PMID35034286
OpenAlexW4206424886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.