Evidence map›Paper›PMID 35034194›Full record

Trial reportEuropean journal of applied physiology2022

Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial.

Mauro Nardon, Massimo Venturelli, Federico Ruzzante, Valter D Longo, Matteo Bertucco

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04476615 (Effects of Fasting-mimicking Diet on Central and Peripheral Components of Fatigue, Muscular Resistance), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04476615 nacompletednot on this map

Effects of Fasting-mimicking Diet on Central and Peripheral Components of Fatigue, Muscular Resistance

TypeinterventionalSponsorUniversita di VeronaRan2017 to 2020Enrolled24ConditionsFatigue, Muscle, Heart, Fasting, Diet, HealthyArmsFasting-Mimicking Diet (ProLon®), Placebo bars
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. [The Role of Fasting-Mimicking Diet in Cancer Therapy: Mechanisms, Challenges, and Clinical Prospects].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mauro NardonDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Felice Casorati 43, 37131, Verona, Italy.
Massimo VenturelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Felice Casorati 43, 37131, Verona, Italy.
Federico RuzzanteDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Felice Casorati 43, 37131, Verona, Italy.
Valter D LongoLongevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Matteo BertuccoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Felice Casorati 43, 37131, Verona, Italy. matteo.bertucco@univr.it.ORCID http://orcid.org/0000-0002-5653-6387
University of Verona · ITUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the short- and long-term effects of the Fasting-Mimicking-Diet (FMD) intervention on neuromuscular parameters of force production in healthy young men.

methodsTwenty-four physically active men completed the study. Participants were randomly assigned to Fasting-Mimicking (FMD) or Normal Diet (ND) and asked to follow three cycles of dietary intervention. Neuromuscular parameters of force production during maximal voluntary isometric contractions (MVCs) with the leg extensors muscles and anthropometrics were measured at baseline (T0), at the end of the first cycle (T1), and 7-10 days after the 3rd cycle of the nutritional intervention (T2). The study was registered on Clinicaltrials.gov (No. NCT04476615).

resultsThere was a significant decrease in body mass at T1 for FMD (- 2.6 kg, ∆ from baseline, on average; p < 0.05) but not in ND (- 0.1 kg;). Neuromuscular parameters of force production, muscle volume, and MVC torque did not change or differ between groups across visits. Results were similar even when parameters were normalized by muscle volume.

conclusionThe consumption of FMD in a group of young healthy male subjects showed to be feasible, and it did not affect neuromuscular parameters of force production. The results suggest that FMD could be safely adopted by strength athletes without detrimental effects on force and muscle volume. Further research in clinical population at risk of muscle mass loss, such as elderly and obese subjects with sarcopenia, is warranted.

Indexed as

DietFastingAdolescentAdultBody Mass IndexElectromyographyHumansIsometric ContractionLegMaleMuscle, SkeletalTorqueFastingFasting-Mimicking-DietMuscle forceNeuromuscular performanceThe twitch interpolation technique

Identifiers

PMID35034194
OpenAlexW4206079152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.