Evidence map›Paper›PMID 35034099›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022

Associations among locus coeruleus catecholamines, tau pathology, and memory in aging.

Claire J Ciampa, Jourdan H Parent, Theresa M Harrison, Rebekah M Fain, Matthew J Betts, Anne Maass, Joseph R Winer, Suzanne L Baker, Mustafa Janabi, Daniella J Furman and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Vulnerability of locus coeruleus connections to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Attenuated pupillary response during visual search in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Alzheimer's Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  8. Review
  9. Article
  10. Age-Related Increase in Locus Ceruleus Activity and Connectivity with the Prefrontal Cortex during Ambiguity Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Claire J Ciampa *Department of Psychology, Brandeis University, Waltham, MA, 02453, USA.
Jourdan H Parent *Department of Psychology, Brandeis University, Waltham, MA, 02453, USA.
Theresa M HarrisonHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Rebekah M FainDepartment of Psychology, Brandeis University, Waltham, MA, 02453, USA.
Matthew J BettsInstitute of Cognitive Neurology and Dementia Research, Otto von Guericke University, Magdeburg, 39106, Germany.
Anne MaassDeutsches Zentrum für Neurodegenerative Erkrankungen, Magdeburg, 39120, Germany.
Joseph R WinerHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Suzanne L BakerLawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Mustafa JanabiLawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Daniella J FurmanHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.
Mark D'EspositoHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-3462-006X
William J JagustHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-4458-113X
Anne S BerryDepartment of Psychology, Brandeis University, Waltham, MA, 02453, USA. anneberry@brandeis.edu.ORCID http://orcid.org/0000-0002-5086-3643
Lawrence Berkeley National Laboratory · USBrandeis University · USUniversity of California, Berkeley · USGerman Center for Neurodegenerative Diseases · DEUniversity of California, San Francisco · US

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Mechanisms of Alzheimer's Disease Progression in the Aging BrainR01AG062542 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2019 to 2023
$4.2M
Aging Brain, Cognition, and DopamineR01AG044292 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2013 to 2017
$3.6M
Dopamine and Frontostriatal FunctionR01DA034685 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI D'ESPOSITO, MARK · 2013 to 2017
$3.4M
Age effects on memory and reward systems in decision makingR00AG058748 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2019 to 2021
$745k
Locus Coeruleus Biomarker Development for Early Detection of Alzheimers Disease in HumansR03AG072328 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2021 to 2022
$325k
Age effects on memory and reward systems in decision makingK99AG058748 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BERRY, ANNE SHIVELY · 2018 to 2019
$250k
Characterizing sleep-wake activity patterns to detect early Alzheimer's disease in normal older individualsF32AG074625 · NIA · STANFORD UNIVERSITY · PI WINER, JOSEPH ROBERT · 2021 to 2023
$207k
Relationships between tau pathology, sleep physiology and memory in agingF31AG063428 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WINER, JOSEPH ROBERT · 2019 to 2020
$59k
NIA NIH HHS F31 AG063428NIA NIH HHS F32 AG074625NIA NIH HHS K99 AG058748NIA NIH HHS R00 AG058748NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG044292NIA NIH HHS R01 AG062542NIA NIH HHS R03 AG072328NIDA NIH HHS R01 DA034685
6 · The paper itself

Abstract

The locus coeruleus (LC) is the brain's major source of the neuromodulator norepinephrine, and is also profoundly vulnerable to the development of Alzheimer's disease (AD)-related tau pathology. Norepinephrine plays a role in neuroprotective functions that may reduce AD progression, and also underlies optimal memory performance. Successful maintenance of LC neurochemical function represents a candidate mechanism of protection against the propagation of AD-related pathology and may facilitate the preservation of memory performance despite pathology. Using [

Indexed as

Alzheimer DiseaseLocus CoeruleusAgedAgingAmyloid beta-PeptidesCatecholaminesHumansNorepinephrinePositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesCatecholaminesNorepinephrinetau Proteins

Identifiers

PMID35034099
PMCPMC8938463
OpenAlexW4206601274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.