ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Measuring maladaptive avoidance: from animal models to clinical anxiety.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 73 citations in OpenAlex.
- Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related disorders.Molecular psychiatry · 2026Article
- Impaired midfrontal‑motor theta phase synchronization characterizes maladaptive motivational behavior in people with obsessive‑compulsive disorder.PLoS biology · 2026Article
- Latent subdimensions of anxiety and depression differentially influence exertion of effort in pursuit of reward versus avoidance of threat.Translational psychiatry · 2026Article
- Male Sapap3 knockout mice show threat bias under conflict during platform-mediated avoidance task: effects of extinction with response prevention and implications for obsessive compulsive disorder.Translational psychiatry · 2026Article
- MRI-Related Claustrophobia: Patient-Reported Experience and Associated Factors in a Makkah Region Cohort.Tomography (Ann Arbor, Mich.) · 2026Article
- Cortical-limbic circuit dynamics of approach-avoidance conflict in humans.Nature communications · 2026Article
- From Acute Stress to Long-Term Dysregulation: Changes in Hematological and Hormonal Parameters in the Long-Term Post-Stress Period in a Modified SPS&S Model.Biomedicines · 2026Article
- Psychological flexibility, distress, and coping in ovarian cancer survivors.Journal of psychosocial oncology · 2026Article
- Homeostasis after injury: How intertwined inference and control underpin post-injury pain and behaviour.PLoS computational biology · 2026Article
- Female rats adopt a safety-first strategy in a high-conflict platform mediated avoidance task.Frontiers in behavioral neuroscience · 2026Article
- Ego-Tucking: a novel psychological mechanism of strategic retrenchment and resilience among Chinese youth.Frontiers in psychology · 2026Article
- Use of Single Prolonged Stress to Model Post-traumatic Stress Disorder in Rodents: What We Found and Where to Next?Current neuropharmacology · 2026Review
- The mediating role of physical exercise in the relationship between university students' interpersonal disturbance and conflict resolution strategies.Frontiers in psychology · 2026Article
- Heterogeneity in health anxiety among medical students and HPV testing acceptability: the mediating role of eHealth literacy from a person-centered perspective.Frontiers in public health · 2026Article
- Mapping affective pathways to compulsion: Insights from an aversive devaluation approach.Journal of behavioral addictions · 2025Article
- Approach-Avoidance Conflict Paradigms in Animal and Human Studies of Anxiety-A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2025Review
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- Assessing Mental Health Literacy Among Undergraduate Nursing Students in South Africa.Nursing reports (Pavia, Italy) · 2025Article
- Interplay among bedtime procrastination, sleep patterns, and subjective wellbeing in the Indian population: An observational study.World journal of psychiatry · 2025Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Avoiding stimuli that predict danger is required for survival. However, avoidance can become maladaptive in individuals who overestimate threat and thus avoid safe situations as well as dangerous ones. Excessive avoidance is a core feature of anxiety disorders, post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD). This avoidance prevents patients from confronting maladaptive threat beliefs, thereby maintaining disordered anxiety. Avoidance is associated with high levels of psychosocial impairment yet is poorly understood at a mechanistic level. Many objective laboratory assessments of avoidance measure adaptive avoidance, in which an individual learns to successfully avoid a truly noxious stimulus. However, anxiety disorders are characterized by maladaptive avoidance, for which there are fewer objective laboratory measures. We posit that maladaptive avoidance behavior depends on a combination of three altered neurobehavioral processes: (1) threat appraisal, (2) habitual avoidance, and (3) trait avoidance tendency. This heterogeneity in underlying processes presents challenges to the objective measurement of maladaptive avoidance behavior. Here we first review existing paradigms for measuring avoidance behavior and its underlying neural mechanisms in both human and animal models, and identify how existing paradigms relate to these neurobehavioral processes. We then propose a new framework to improve the translational understanding of maladaptive avoidance behavior by adapting paradigms to better differentiate underlying processes and mechanisms and applying these paradigms in clinical populations across diagnoses with the goal of developing novel interventions to engage specific identified neurobehavioral targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.