ArticleNeuroImage2022
A large-scale investigation of white matter microstructural associations with reading ability.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- The Relation of the Home Literacy Environment to White Matter Pathways Associated with Language in Children 5-8 Years Old.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Twin differences in lateral ventricle size accompany twin differences in phonological decoding.Brain structure & function · 2025Article
- Reading and White Matter Development: A Systematic Review of Neuroplastic Changes in Literacy.Children (Basel, Switzerland) · 2025Review
- Phonological decoding ability is associated with fiber density of the left arcuate fasciculus longitudinally across reading development.Developmental cognitive neuroscience · 2025Article
- Consistent cerebellar pathway-cognition associations across pre-adolescents & young adults: a diffusion MRI study of 9000+ participants.bioRxiv : the preprint server for biology · 2025Article
- Development of the arcuate fasciculus is linked to learning gains in reading.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Impact of COVID-19 School Closures on White Matter Plasticity in the Reading Network.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Functional connectivity between the uncinate fasciculus and frontotemporal semantic system supports reading comprehension in adolescents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Distinct impact modes of polygenic disposition to dyslexia in the adult brain.Science advances · 2024Article
- The neocortical infrastructure for language involves region-specific patterns of laminar gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sex Differences in White Matter Diffusivity in Children with Developmental Dyslexia.Children (Basel, Switzerland) · 2024Article
- Investigating Dyslexia through Diffusion Tensor Imaging across Ages: A Systematic Review.Brain sciences · 2024Review
- White matter and literacy: A dynamic system in flux.Developmental cognitive neuroscience · 2024Article
- White matter microstructural plasticity associated with educational intervention in reading disability.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Exploring Genetic and Neural Risk of Specific Reading Disability within a Nuclear Twin Family Case Study: A Translational Clinical Application.Journal of personalized medicine · 2023Article
- Arcuate fasciculus and pre-reading language development in children with prenatal alcohol exposure.Frontiers in neuroscience · 2023Article
- Fiber-specific structural properties relate to reading skills in children and adolescents.eLife · 2022Article
- Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology.Neurocase · 2022Article
- White matter properties underlying reading abilities differ in 8-year-old children born full term and preterm: A multi-modal approach.NeuroImage · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Reading involves the functioning of a widely distributed brain network, and white matter tracts are responsible for transmitting information between constituent network nodes. Several studies have analyzed fiber bundle microstructural properties to shed insights into the neural basis of reading abilities and disabilities. Findings have been inconsistent, potentially due to small sample sizes and varying methodology. To address this, we analyzed a large data set of 686 children ages 5-18 using state-of-the-art neuroimaging acquisitions and processing techniques. We searched for associations between fractional anisotropy (FA) and single-word and single-nonword reading skills in children with diverse reading abilities across multiple tracts previously thought to contribute to reading. We also looked for group differences in tract FA between typically reading children and children with reading disabilities. FA of the white matter increased with age across all participants. There were no significant correlations between overall reading abilities and tract FAs across all children, and no significant group differences in tract FA between children with and without reading disabilities. There were associations between FA and nonword reading ability in older children (ages 9 and above). Higher FA in the right superior longitudinal fasciculus (SLF) and left inferior cerebellar peduncle (ICP) correlated with better nonword reading skills. These results suggest that letter-sound correspondence skills, as measured by nonword reading, are associated with greater white matter coherence among older children in these two tracts, as indexed by higher FA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.