ArticleJACC. Cardiovascular imaging2022
18F-GP1 Positron Emission Tomography and Bioprosthetic Aortic Valve Thrombus.
Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
18F-GP1 Positron Emission Tomography-computed Tomography to Detect Bioprosthetic Aortic Valve Thrombosis; the Biothrombus Study.
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.Circulation · 2026Observational
- Imaging small dynamic lesions using positron emission tomography and computed tomography: anEuropean heart journal. Imaging methods and practice · 2025Article
- Uncovering atherosclerotic cardiovascular disease by PET imaging.Nature reviews. Cardiology · 2024Review
- Thrombosis of Bioprosthetic Aortic Valve: Is the Entire Arsenal Deployed?Reviews in cardiovascular medicine · 2024Review
- Multi-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice.American heart journal plus : cardiology research and practice · 2024Article
- Multimodal Cardiac Imaging in the Assessment of Patients Who Have Suffered a Cardioembolic Stroke: A Review.Journal of cardiovascular development and disease · 2023Review
- Serum lipoprotein(a) and bioprosthetic aortic valve degeneration.European heart journal. Cardiovascular Imaging · 2023Article
- Bioprosthetic Aortic Valve Thrombosis and Literature Review.Journal of cardiovascular development and disease · 2022Article
- Molecular Imaging of Aortic Valve Stenosis with Positron Emission Tomography.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Targeted Molecular Imaging Sheds Light on Bioprosthetic Aortic Valve Thrombosis.JACC. Cardiovascular imaging · 2022Article
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Authors and funding
33 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundBioprosthetic valve thrombosis may have implications for valve function and durability.
objectivesUsing a novel glycoprotein IIb/IIIa receptor radiotracer 18F-GP1, we investigated whether positron emission tomography (PET)-computed tomography (CT) could detect thrombus formation on bioprosthetic aortic valves.
methodsEx vivo experiments were performed on human platelets and explanted bioprosthetic aortic valves. In a prospective cross-sectional study, patients with either bioprosthetic or normal native aortic valves underwent echocardiography, CT angiography, and 18F-GP1 PET-CT.
resultsFlow cytometric analysis, histology, immunohistochemistry, and autoradiography demonstrated selective binding of 18F-GP1 to activated platelet glycoprotein IIb/IIIa receptors and thrombus adherent to prosthetic valves. In total, 75 participants were recruited: 53 with bioprosthetic valves (median time from implantation 37 months [IQR: 12-80 months]) and 22 with normal native aortic valves. Three participants had obstructive valve thrombosis, and a further 3 participants had asymptomatic hypoattenuated leaflet thickening on CT angiography. All bioprosthetic valves, but none of the native aortic valves, demonstrated focal 18F-GP1 uptake on the valve leaflets: median maximum target-to-background ratio 2.81 (IQR: 2.29-3.48) vs 1.43 (IQR: 1.28-1.53) (P < 0.001). Higher 18F-GP1 uptake was independently associated with duration of valve implantation and hypoattenuated leaflet thickening. All 3 participants with obstructive valve thrombosis were anticoagulated for 3 months, leading to resolution of their symptoms, improvement in mean valve gradients, and a reduction in 18F-GP1 uptake.
conclusionsAdherence of activated platelets is a common and sustained finding on bioprosthetic aortic valves. 18F-GP1 uptake is higher in the presence of thrombus, regresses with anticoagulation, and has potential use as an adjunctive clinical tool. (18F-GP1 PET-CT to Detect Bioprosthetic Aortic Valve Thrombosis; NCT04073875).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.