Observational studyScandinavian journal of trauma, resuscitation and emergency medicine2022
Optimal cardiopulmonary resuscitation duration for favorable neurological outcomes after out-of-hospital cardiac arrest.
Observational study in Scandinavian journal of trauma, resuscitation and emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Neurological outcome predictors after extracorporeal cardiopulmonary resuscitation: a systematic review.Systematic reviews · 2025Pooled it
- Outcomes of odontoid fractures with associated cardiac arrest: retrospective bi-center case series and systematic literature review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Pooled it
- Time from Cardiopulmonary Resuscitation Initiation to Prehospital Return of Spontaneous Circulation and Downstream Outcomes Among Adult Out-of-Hospital Cardiac Arrest Patients Achieving Field ROSC: A 2015-2023 Smart Advanced Life Support Registry Study.Diagnostics (Basel, Switzerland) · 2026Article
- Optimal Low-Flow Time of Extracorporeal Cardiopulmonary Resuscitation for Favorable Neurological Outcomes: A Risk-Stratified Approach.Journal of clinical medicine · 2026Article
- Resuscitation-induced consciousness: clinical, philosophical, ethical, and legal aspects.Resuscitation plus · 2025Article
- Femoral Vessel Occlusion Enhances Cardiac and Cerebral Perfusion in a Porcine Model of Cardiac Arrest.Journal of the American Heart Association · 2025Article
- Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest.Resuscitation plus · 2025Article
- Appropriate cardiopulmonary resuscitation duration and predictors of return of spontaneous circulation in traumatic cardiac arrest.BMC emergency medicine · 2025Observational
- From Cardiac Arrest to Survival: Managing Acute Type A Aortic Dissection With Emergent Surgery.Cureus · 2025Article
- Artificial Intelligence in Cardiopulmonary Resuscitation: Revolutionizing Resuscitation Through Precision and Prediction - A Narrative Review.Vascular health and risk management · 2025Review
- Assessing Key Factors Influencing Successful Resuscitation Outcomes in Out-of-Hospital Cardiac Arrest (OHCA).Journal of clinical medicine · 2024Article
- Optimal timing of ultra-early diffusion-weighted MRI in out-of-hospital cardiac arrest patients based on a retrospective multicenter cohort study.Scientific reports · 2024Article
- Clinicians' experience of barriers and facilitators to care delivery of an extracorporeal cardiopulmonary resuscitation service for out-of-hospital cardiac arrest: a qualitative survey.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Article
- Mortality Predictors and Neurological Outcomes Following Extracorporeal Cardiopulmonary Resuscitation (eCPR): A Single-Center Retrospective Study.Journal of cardiovascular development and disease · 2024Article
- Views and perceptions of advanced life support practitioners on initiating, withholding and terminating resuscitation in out-of-hospital cardiac arrest in the Emergency Medical Services of South Africa.Resuscitation plus · 2024Article
- ECPR-the evolving role in cardiac arrest.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- What factors are effective on the CPR duration of patients under extracorporeal cardiopulmonary resuscitation: a single-center retrospective study.International journal of emergency medicine · 2024Article
- Observational
- Association between cardiopulmonary resuscitation duration and survival after out-of-hospital cardiac arrest according: a first nationwide study in France.Internal and emergency medicine · 2024Observational
- Extracorporeal cardiopulmonary resuscitation in 2023.Intensive care medicine experimental · 2023Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundA favorable neurological outcome is closely related to patient characteristics and total cardiopulmonary resuscitation (CPR) duration. The total CPR duration consists of pre-hospital and in-hospital durations. To date, consensus is lacking on the optimal total CPR duration. Therefore, this study aimed to determine the upper limit of total CPR duration, the optimal cut-off time at the pre-hospital level, and the time to switch from conventional CPR to alternative CPR such as extracorporeal CPR.
methodsWe conducted a retrospective observational study using prospective, multi-center registry of out-of-hospital cardiac arrest (OHCA) patients between October 2015 and June 2019. Emergency medical service-assessed adult patients (aged ≥ 18 years) with non-traumatic OHCA were included. The primary endpoint was a favorable neurological outcome at hospital discharge.
resultsAmong 7914 patients with OHCA, 577 had favorable neurological outcomes. The optimal cut-off for pre-hospital CPR duration in patients with OHCA was 12 min regardless of the initial rhythm. The optimal cut-offs for total CPR duration that transitioned from conventional CPR to an alternative CPR method were 25 and 21 min in patients with initial shockable and non-shockable rhythms, respectively. In the two groups, the upper limits of total CPR duration for achieving a probability of favorable neurological outcomes < 1% were 55-62 and 24-34 min, respectively, while those for a cumulative proportion of favorable neurological outcome > 99% were 43-53 and 45-71 min, respectively.
conclusionsHerein, we identified the optimal cut-off time for transitioning from pre-hospital to in-hospital settings and from conventional CPR to alternative resuscitation. Although there is an upper limit of CPR duration, favorable neurological outcomes can be expected according to each patient's resuscitation-related factors, despite prolonged CPR duration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.