Evidence map›Paper›PMID 35033177›Full record

ArticleDiabetology & metabolic syndrome2022

Association between life-course cigarette smoking and metabolic syndrome: a discovery-replication strategy.

Jingya Wang, Yang Bai, Zihang Zeng, Jun Wang, Ping Wang, Yongai Zhao, Weili Xu, Yun Zhu, Xiuying Qi

Abstract read
In one paragraph

Article in Diabetology & metabolic syndrome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  13. Metabolic syndrome prevalence and cardiovascular disease risk among school teachers.International journal of occupational medicine and environmental health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingya Wang *Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping district, 300070, Tianjin, People's Republic of China.
Yang Bai *Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping district, 300070, Tianjin, People's Republic of China.
Zihang ZengDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping district, 300070, Tianjin, People's Republic of China.
Jun WangTianjin Santan Hospital, Nankai District, Tianjin, People's Republic of China.
Ping WangTianjin Santan Hospital, Nankai District, Tianjin, People's Republic of China.
Yongai ZhaoTianjin Santan Hospital, Nankai District, Tianjin, People's Republic of China.
Weili XuDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping district, 300070, Tianjin, People's Republic of China.
Yun ZhuDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping district, 300070, Tianjin, People's Republic of China. yun.zhu@tmu.edu.cn.ORCID http://orcid.org/0000-0002-5864-0794
Xiuying QiDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping district, 300070, Tianjin, People's Republic of China. qixiuying@tmu.edu.cn.

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
MONITORING SOCIAL CHANGE: HEALTH, REPRODUCTION, AGINGR01HD030880 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S, POPKIN, BARRY M · 1994 to 2024
$27.0M
CHILD HEALTH EFFECTS OF RAPID SOCIO-DEMOGRAPHIC CHANGER01HD038700 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2000 to 2004
$1.5M
National Natural Science Foundation of China No. 81771519NICHD NIH HHS R01 HD030880NICHD NIH HHS R01 HD038700NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

backgroundThe relation between cigarette smoking and metabolic syndrome (MetS) remains unclear, and previous studies focusing on MetS are limited in sample size. We investigated the association between life-course smoking and MetS with independent discovery and replication samples.

methodsPreliminary analysis utilized data from an annual cross-sectional survey of 15,222 participants aged ≥ 60 years in Tianjin, China. Suggestive associations were followed-up in 8565 adults from the China Health and Nutrition Survey. MetS was identified according to the criteria of the Chinese Diabetes Society in 2013. Life-course smoking was assessed by a comprehensive smoking index (CSI), based on information on smoking intensity, duration, and time since cessation across life-course, collected through standard questionnaires. Participants were divided into four groups: non-smokers; and the tertiles of CSI in ever smokers. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between life-course smoking and MetS.

resultsIn the discovery sample, ORs of MetS were 2.01 (95%CI: 1.64-2.47) and 1.76 (95%CI: 1.44-2.16) for smokers in the highest and second tertile of CSI compared with never smokers. Potential interaction was shown for age, with increased ORs for MetS associated with smoking limited to individuals who aged < 70 years (P

conclusionsLife-course cigarette smoking is associated with an increased odds of MetS, especially among individuals who aged < 70 years.

Indexed as

Cigarette smokingCross-sectional studyDiscovery-replication strategyInteractionMetabolic syndrome

Identifiers

PMID35033177
PMCPMC8761321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.