Evidence map›Paper›PMID 35033099›Full record

ArticlePediatric rheumatology online journal2022

Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis.

Hanne Van Der Heijden, Benoit Fatou, Diana Sibai, Kacie Hoyt, Maria Taylor, Kin Cheung, Jordan Lemme, Mariesa Cay, Benjamin Goodlett, Jeffery Lo and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Hanne Van Der Heijden *Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Benoit Fatou *Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Diana SibaiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kacie HoytDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Maria TaylorDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kin CheungBioSAS Consulting, Inc, Wellesley, MA, USA.
Jordan LemmeDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Mariesa CayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin GoodlettDivision of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jeffery LoDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Melissa M HazenDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Olha HalyabarDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Esra MeidanDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rudy SchreiberFaculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, The Netherlands.
Camilo JaimesDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kirsten EcklundDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren A HendersonDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Margaret H ChangDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Peter A NigrovicDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Robert P SundelDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Hanno SteenDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. hanno.steen@childrens.harvard.edu.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. jaymin.upadhyay@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-8682-163X
Boston Children's Hospital · USMaastricht University · NLWellesley College · US

Funding

Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
NIAMS NIH HHS 2P30AR070253.NIAMS NIH HHS P30 AR070253
6 · The paper itself

Abstract

introductionJuvenile idiopathic arthritis (JIA) is a cluster of autoimmune rheumatic diseases occurring in children 16 years of age or less. While it is well-known that pain may be experienced during inflammatory and non-inflammatory states, much remains ambiguous regarding the molecular mechanisms that may drive JIA pain. Thus, in this pilot study, we explored the variability of the serum proteomes in relation to pain severity in a cohort of JIA patients.

methodsSerum samples from 15 JIA patients (male and female, 12.7 ± 2.8 years of age) were assessed using liquid chromatography/mass spectrometry (LC/MS). Correlation analyses were performed to determine the relationships among protein levels and self-reported clinical pain severity. Additionally, how the expression of pain-associated proteins related to markers of inflammation (Erythrocyte Sedimentation Rate (ESR)) or morphological properties of the central nervous system (subcortical volume and cortical thickness) implicated in JIA were also evaluated.

results306 proteins were identified in the JIA cohort of which 14 were significantly (p < 0.05) associated with clinical pain severity. Functional properties of the identified pain-associated proteins included but were not limited to humoral immunity (IGLV3.9), inflammatory response (PRG4) and angiogenesis (ANG). Associations among pain-associated proteins and ESR (IGHV3.9, PRG4, CST3, VWF, ALB), as well as caudate nucleus volume (BTD, AGT, IGHV3.74) and insular cortex thickness (BTD, LGALS3BP) were also observed.

conclusionsThe current proteomic findings suggest both inflammatory- and non-inflammatory mediated mechanisms as potential factors associated with JIA pain. Validation of these preliminary observations using larger patient cohorts and a longitudinal study design may further point to novel serologic markers of pain in JIA.

Indexed as

AdolescentArthritis, JuvenileBiomarkersChildFemaleHumansInflammationMalePain MeasurementPilot ProjectsProteomicsBiomarkersInflammationJuvenile idiopathic arthritisMass spectrometryPainProteomics

Identifiers

PMID35033099
PMCPMC8761318
OpenAlexW4205708618

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.