Evidence map›Paper›PMID 35032457›Full record

ArticleBiophysical journal2022

Hydraulic permeability and compressive properties of porcine and human synovium.

Milad Rohanifar, Benjamin B Johnston, Alexandra L Davis, Young Guang, Kayla Nommensen, James A J Fitzpatrick, Christine N Pham, Lori A Setton

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Pirfenidone Attenuates Fibrosis and Neovascularization in 3D Spheroid-Laden Hydrogel Culture.Journal of tissue engineering and regenerative medicine · 2026
    Article
  2. Article
  3. Review
  4. Transport across the thoracic aortic wall: implications for aneurysm pathobiology, diagnosis, and treatment.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Milad RohanifarDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.
Benjamin B JohnstonDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.
Alexandra L DavisDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.
Young GuangDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.
Kayla NommensenDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.
James A J FitzpatrickDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri; Department of Neuroscience and Cell Biology & Physiology, Washington University School of Medicine, St. Louis, Missouri.
Christine N PhamDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri.
Lori A SettonDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri. Electronic address: setton@wustl.edu.
Washington University in St. Louis · US

Funding

Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Intra-Articular Delivery of Sustained Release NF-kB Antagonists In ArthritisR01AR070975 · NIAMS · WASHINGTON UNIVERSITY · PI SETTON, LORI A. · 2017 to 2021
$1.7M
NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR070975
6 · The paper itself

Abstract

The synovium is a multilayer connective tissue separating the intra-articular spaces of the diarthrodial joint from the extra-synovial vascular and lymphatic supply. Synovium regulates drug transport into and out of the joint, yet its material properties remain poorly characterized. Here, we measured the compressive properties (aggregate modulus, Young's modulus, and Poisson's ratio) and hydraulic permeability of synovium with a combined experimental-computational approach. A compressive aggregate modulus and Young's modulus for the solid phase of synovium were quantified from linear regression of the equilibrium confined and unconfined compressive stress upon strain, respectively (H

Indexed as

Cartilage, ArticularAnimalsCompressive StrengthElasticityHumansModels, BiologicalPermeabilityStress, MechanicalSwineSynovial Membrane

Identifiers

PMID35032457
PMCPMC8874024
OpenAlexW4206656880

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.