ArticleThe New phytologist2022
CLAVATA modulates auxin homeostasis and transport to regulate stem cell identity and plant shape in a moss.
Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 45 citations in OpenAlex.
- CLE pathways in plant development: recent advances and future perspectives.Journal of experimental botany · 2025Review
- An updated history of TDIF-PXY signalling: a study in cell fate and tissue patterning.The New phytologist · 2025Review
- The role of auxin-mediated gene activation in the bryophyte, Physcomitrium patens.Journal of experimental botany · 2025Article
- Diversification of CLE expression patterns and nonmeristematic roles for CLAVATA receptor-like kinases in a moss.The New phytologist · 2025Article
- The rise of CLAVATA: evidence for CLAVATA3 and WOX signaling in the fern gametophyte.The Plant journal : for cell and molecular biology · 2025Article
- CLE peptides act via the receptor-like kinase CRINKLY 4 inPlant signaling & behavior · 2024Article
- Male Germ Cell Specification in Plants.International journal of molecular sciences · 2024Review
- Functional Modules in the Meristems: "Tinkering" in Action.Plants (Basel, Switzerland) · 2023Review
- The TOPLESS corepressor regulates developmental switches in the bryophyte Physcomitrium patens that were critical for plant terrestrialisation.The Plant journal : for cell and molecular biology · 2023Article
- A network of CLAVATA receptors buffers auxin-dependent meristem maintenance.Nature plants · 2023Article
- Clade-D auxin response factors regulate auxin signaling and development in the moss Physcomitrium patens.PLoS biology · 2023Article
- Diverse branching forms regulated by a core auxin transport mechanism in plants.Development (Cambridge, England) · 2023Article
- Unravelling 3D growth in the moss Physcomitrium patens.Essays in biochemistry · 2022Article
- How was apical growth regulated in the ancestral land plant? Insights from the development of non-seed plants.Plant physiology · 2022Review
- Evolution of meristem zonation by CLE gene duplication in land plants.Nature plants · 2022Review
- Cytokinin-CLAVATA cross-talk is an ancient mechanism regulating shoot meristem homeostasis in land plants.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Leaf Morphogenesis: Insights From the MossFrontiers in plant science · 2021Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CLAVATA pathway is a key regulator of stem cell function in the multicellular shoot tips of Arabidopsis, where it acts via the WUSCHEL transcription factor to modulate hormone homeostasis. Broad-scale evolutionary comparisons have shown that CLAVATA is a conserved regulator of land plant stem cell function, but CLAVATA acts independently of WUSCHEL-like (WOX) proteins in bryophytes. The relationship between CLAVATA, hormone homeostasis and the evolution of land plant stem cell functions is unknown. Here we show that in the moss, Physcomitrella (Physcomitrium patens), CLAVATA affects stem cell activity by modulating hormone homeostasis. CLAVATA pathway genes are expressed in the tip cells of filamentous tissues, regulating cell identity, filament branching, plant spread and auxin synthesis. The receptor-like kinase PpRPK2 plays the major role, and Pprpk2 mutants have abnormal responses to cytokinin, auxin and auxin transport inhibition, and show reduced expression of PIN auxin transporters. We propose a model whereby PpRPK2 modulates auxin gradients in filaments to determine stem cell identity and overall plant form. Our data indicate that CLAVATA-mediated auxin homeostasis is a fundamental property of plant stem cell function, probably exhibited by the last shared common ancestor of land plants.
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