Evidence map›Paper›PMID 35032222›Full record

ArticleClinical rheumatology2022

Dysfunction of CD27

Wei Zhang, Yong-Fu Wang, Fan-Lei Hu, Fu-Ai Lu, Tao Wu, Yue-Lan Feng, Ke Li

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wei ZhangCore Research Laboratory, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.ORCID http://orcid.org/0000-0002-8546-3236
Yong-Fu WangDepartment of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Institute of Immunology and Rheumatology, Baotou Medical College, Inner Mongolia Key Laboratory of Autoimmunity, Baotou, 014010, China.
Fan-Lei HuDepartment of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Fu-Ai LuDepartment of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Institute of Immunology and Rheumatology, Baotou Medical College, Inner Mongolia Key Laboratory of Autoimmunity, Baotou, 014010, China.
Tao WuDepartment of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Institute of Immunology and Rheumatology, Baotou Medical College, Inner Mongolia Key Laboratory of Autoimmunity, Baotou, 014010, China.
Yue-Lan FengDepartment of Ophthalmology, First Hospital Affiliated to Baotou Medical College, 41 Linyin Road, Baotou, 014010, China.
Ke LiCore Research Laboratory, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China. ke.li@mail.xjtu.edu.cn.
Baotou Medical College · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNPeking University · CN

Funding

The Inner Mongolia Autonomous Region Science and Technology Plan Project 201802089The Inner Mongolia Autonomous Region Science and Technology Plan Project 2019GG052The National Nature Science Foundation of China 81860295The Nature Science Foundation of Inner Mongolia 2017MS0809The Nature Science Foundation of Inner Mongolia 2021MS08047
6 · The paper itself

Abstract

objectiveThe apoptotic signaling pathway is obviously disordered in systemic lupus erythematosus (SLE). Natural IgM (nIgM) is important in clearing apoptotic cells and preventing them from triggering deleterious autoimmunity. B-1 and innate-like B (ILBs) cells are the main nIgM producers. Human CD27

methodsPeripheral blood sample of 50 SLE patients and 50 healthy controls were collected, and twelve SLE patients were assessed in a follow-up study. The amount of CD27

resultThe amounts of CD27

conclusionThe amounts of CD27

Indexed as

B-Lymphocyte SubsetsLupus Erythematosus, SystemicFollow-Up StudiesHumansImmunoglobulin DImmunoglobulin MInterleukin-10Tumor Necrosis Factor Receptor Superfamily, Member 7Immunoglobulin DImmunoglobulin MInterleukin-10Tumor Necrosis Factor Receptor Superfamily, Member 7CD27+IgD+ B cellsInnate-like B cellsNatural IgMSystemic lupus erythematosus

Identifiers

PMID35032222
OpenAlexW4225254134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.